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TranscriptomicsTargeted disruption of the BCL9/beta-catenin complex in cancer
Stabilized Alpha-Helix peptides of BCL9 HD2 (SAH-BCL9) block BCL9 and B9L interactions with beta-catenin and specifically downregulate Wnt target gene expression. RNA from triplicate SAH-BCL9B- and vehicle-treated DLD1 samples (10 µM each for 12 hours) was hybridized to Affymetrix Human U133 Plus 2....
ORGANISM(S): Homo sapiens 
2012-08-23 | E-GEOD-33143 | biostudies-arrayexpress
ProteomicsBCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-activator of the Wnt/β-catenin pathway, which play...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016172 | Pride
Bcl9 Paraspeckles Colorectal cancer 
ProteomicsMouse ameloblasts Bcl9 interactors
Bcl9 and Bcl9l (Bcl9l) are commonly thought as beta-catenin-dependent Wnt signaling transcriptional activators. We find however that, in the enamel-producin ameloblasts cells, Bcl9/9l are localiyed in the cytoplasm toward to apical secretory membrane. We performed pull down followed by mass spectrom...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-13 | PXD005449 | Pride
Enamel Ameloblasts Pygo Bcl9 
GenomicsChIP-seq experiment of the beta-catenin co-factor Bcl9 in developing forelimbs.
We isolated ca. 500 forelimbs at 10 days post coitum, and performed ChIP-seq using anti-Bcl9 antibodies. Bcl9 is a beta-catenin transcriptional cofactor, therefore it allows the identification of binding sites of the canonical Wnt signalling-dependent transcriptional complex. This experiment allowed...
ORGANISM(S): Mus musculus 
2019-02-21 | E-MTAB-7652 | biostudies-arrayexpress
GenomicsChIP-seq experiment of the beta-catenin co-factor BCL9 and the T-box transcription factor TBX3 in developing mouse forelimbs.
About 500 forelimbs were isolated at 10.5 days post coitum, and ChIP-seq was performed using anti-BCL9 (Abcam, ab37305) and anti-TBX3 (Santacruz, sc17871) antibodies. BCL9 is a beta-catenin transcriptional cofactor involved in the transcriptional machinery of Wnt target genes. TBX3 is a transcriptio...
ORGANISM(S): Mus musculus 
2020-05-08 | E-MTAB-8997 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment of developing mouse forelimbs, comparing Bcl9/9l mutant with control littermates.
Forelimbs were manually dissected from three individual Bcl9/9l-deltaHD1/deltaHD2 mutants and three control littermates, at 10.5 days post coitum. BCL9 and BCL9L are paralogous beta-catenin cofactors involved in the transcriptional machinery of Wnt target genes.
ORGANISM(S): Mus musculus 
2020-05-08 | E-MTAB-9000 | biostudies-arrayexpress
GenomicsGene expression in DCIS.COM with BCL9 knockdown
Gene expression in DCIS.COM with BCL9 knockdown
PRJNA601728 | ENA
TranscriptomicsscRNA-seq of Bcl9/9l fl/fl;Rosa26-CreERT2 small intestinal organoids
Bcl9/9l fl/fl;Rosa26-CreERT2 small intestinal organoids were exposed to 1uM 4-OHT (or EtOH as a control) for 24 hours to induce recombination and induce a conditional Bcl9 and Bcl9l knockout. Intestinal epithelial cells were isolated 72 hours later for single cell RNA sequencing. BCL9 is a beta-cate...
ORGANISM(S): Mus musculus 
2026-07-07 | E-MTAB-16966 | biostudies-arrayexpress
GenomicsBCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression
BCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression
PRJNA599998 | ENA
ProteomicsPull down of full length and mutant BCL9 (deltaHD1) in mouse colorectal tumors and colonic epithelium
Bcl9 and Bcl9l (Bcl9l) are commonly thought as beta-catenin-dependent Wnt signaling transcriptional activators. Here we searched for BCL9 interacts that could explain the PYGO-independent phenotype induced be the loss of the HD1 (PYGO-binding) domain of BCL9
ORGANISM(S): Mus musculus (Mouse) 
2020-08-10 | PXD018805 | Pride
Colorectal tumor Transcription Wnt signalling 
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