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ProteomicsSILAC experiment of HEK 293 cells upon RPS26 silencing
In recent years, there is emerging pool of evidence suggesting that ribosomal composition plays a role in selection of transcripts that are actively translated at given time and tissue. Some ribosomal subunits are not the core components of 40S ribosome and alternatively can be assembled or disassem...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD047397 | Pride
Rps26 Human Silac 
ProteomicsMass-spectrometry based screening revealing proteins bound to FMR1 mRNA
Short nucleotide repeats are robustly distributed in human genome and contribute to pathogenesis of multiple neurodegenerative disorders such as Fragile X-associated Tremor/Ataxia Syndrome (FXTAS). Pathogenesis of FXTAS is driven by premutation status of CGG repeats expansion (CGGexp) in the 5’UTR r...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD047400 | Pride
Hek Fmr1 Human Mrna Rps26 Rna binding proteins 
ProteomicsProteins binding in vitro to normal and mutant FMR1 5'UTR mRNA
Expanded CGG repeats in the 5’UTR of fragile X messenger ribonucleoprotein 1 (FMR1) gene are translated to mutant protein containing polyglycine stretches (FMRpolyG), which evoke development of neurodegenerative disorder the fragile X-associated tremor/ataxia syndrome (FXTAS). However, little is kno...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD053905 | Pride
Fmr1 Igf2bp3 Expanded cgg repeats Rna pull down Ran translation 
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