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ProteomicsBlood-brain barrier dysfunction in brain metastasis formation in HER2-positive breast cancer
we investigated the role of bioactive molecules secreted by HER2+ BC cells in BBB dysfunction during the formation of the pre-metastatic niche before the onset of BrM. We demonstrate that systemic signaling derived from brain metastatic HER2+ primary tumors instigates BBB dysfunction
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051579 | Pride
Her2+ breast cancer Bbb dysfunction Brain metastasis Secretome 
TranscriptomicsAlbumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.
Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuro...
ORGANISM(S): Rattus norvegicus 
2009-07-15 | E-GEOD-12304 | biostudies-arrayexpress
TranscriptomicsBBBomics - Human Blood Brain Barrier Transcriptomics Hub [RNA-seq]
Functional and structural dysfunction of the blood brain barrier (BBB) leads to severe alterations in brain physiology and is believed to trigger neurodegeneration. To investigate the molecular mechanisms driving the BBB dysfunction, very few human BBB cell culture models are available; of which, th...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-76528 | biostudies-arrayexpress
TranscriptomicsBBBomics - Human Blood Brain Barrier Transcriptomics Hub [miRNA-seq]
Functional and structural dysfunction of the blood brain barrier (BBB) leads to severe alterations in brain physiology and is believed to trigger neurodegeneration. To investigate the molecular mechanisms driving the BBB dysfunction, very few human BBB cell culture models are available;of which, the...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-76530 | biostudies-arrayexpress
UnknownOmics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelae.
Not available
S-EPMC11681072 | biostudies-literature
ProteomicsAPOE4 cell-specific mechanisms underlying cerebrovascular disorder precede neuronal and synaptic dysfunction and cognitive deficits in mice
Apolipoprotein E4 (APOE4), the main susceptibly gene for Alzheimer’s disease1–5, exerts cerebrovascular toxicity6 leading to blood-brain barrier (BBB) breakdown in humans7–9 and APOE4 transgenic mice10–13. Moreover, an early BBB dysfunction predicts cognitive decline in humans7. However, the compre...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-23 | PXD029230 | Pride
Phosphoproteome Alzheimer’s disease Signaling networks Single cell rna-seq Apoe4 Bbb breakdown Interactome Blood-brain barrier 
GenomicsAngiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation.
Angiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation.
PRJNA1208978 | ENA
UnknownA transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption.
Not available
S-EPMC9414148 | biostudies-literature
UnknownBlood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction.
Not available
S-EPMC8475767 | biostudies-literature
TranscriptomicsAngiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation.
Disruption of the blood-brain barrier (BBB) and increased vascular leakage contribute to neuroinflammation in Alzheimer’s disease (AD), driving disease pathogenesis and progression. However, the mechanisms underlying BBB dysfunction and neuroinflammation in AD remain unclear. Angiopoietin-2 (ANGPT2)...
ORGANISM(S): Mus musculus 
2026-04-15 | GSE286360 | GEO
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