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MetabolomicsGRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis

BACKGROUND: Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we iden...

2025-10-19 | MTBLS13178 | MetaboLights
MetabolomicsBCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS (targeted metabolomics)

Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown. Many clinical studies have shown that POI patient...

2024-09-26 | MTBLS6267 | MetaboLights
MetabolomicsBCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS (untargeted lipidomics)

Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown. Many clinical studies have shown that POI patient...

2024-09-26 | MTBLS6249 | MetaboLights
MetabolomicsImpact of host dietary BCAA to gut symbiont-derived lipid profile
Not available
ORGANISM(S): Mus musculus 
ST001910 | MetabolomicsWorkbench
TranscriptomicsBCAA catabolic mutants in prolonged darkness
We used RNA-Seq to ask whether the transcripts for the proposed BCKDH subunits are upregulated in wild-type plants subjected to prolonged darkness. These experiments were performed using rosette leaves from 5-week-old, short-day-grown (8h light/16h dark) Col-0 wild-type plants moved to constant dark...
ORGANISM(S): Arabidopsis thaliana 
2015-04-16 | E-GEOD-67956 | biostudies-arrayexpress
ProteomicsUncoupling Metabolic Health from Thermogenesis via BCAA Flux in Brown Fat
Brown adipose tissue (BAT) is best known for thermogenesis. Whereas numerous studies in rodents found tight associations between the metabolic benefits of BAT and enhanced whole-body energy expenditure, emerging evidence in humans suggests that BAT is protective against Type 2 diabetes independent o...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-15 | PXD044020 | Pride
Brown adipose tissue (bat) Branched-chain amino acids (bcaa) 
MetabolomicsTime sensitive contribution of the BCAA catabolism to the TCA cycle carbons in HK2, 786-O, OS-RC-2 and RFX-631
Not available
ORGANISM(S): Homo sapiens 
ST002225 | MetabolomicsWorkbench
ProteomicsUncoupling Metabolic Health from Thermogenesis via BCAA Flux in Brown Fat
Brown adipose tissue (BAT) is best known for thermogenesis. Whereas numerous studies in rodents found tight associations between the metabolic benefits of BAT and enhanced whole-body energy expenditure, emerging evidence in humans suggests that BAT is protective against Type 2 diabetes independent o...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-15 | PXD043992 | Pride
Brown adipose tissue (bat) Branched-chain amino acids (bcaa) 
ProteomicsThe BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase
Strong associations exist between branched chain amino acids (BCAA) and dysregulated glucose and lipid metabolism, but the underlying mechanisms are not well understood. Here we report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulate branched-chain keto...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-18 | PXD009122 | Pride
Ppm1k Acl Bdk Protein phosphorylation Bcaa 
ProteomicsBCAA insufficiencies lead to premature ovarian insufficiency via ceramide induced elevation of ROS
Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone (FSH). Though POI affects many aspects of women’s health, its major causes remain unknown. Many clinical studies have shown that POI pati...
ORGANISM(S): Homo Sapiens 
2022-10-13 | PXD037353 |
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