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UnknownSmall molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Not available
S-EPMC10412597 | biostudies-literature
ProteomicsDiscovery of small molecule branched-chain ketoacid dehydrogenase kinase 23 (BDK) inhibitors with opposing effects on BDK protein levels
Branched chain ketoacid dehydrogenase kinase (BDK) was immunoprecipitated from hearts of mice that had been treated with BDK inhibitors or vehicle.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-21 | MSV000091341 | MassIVE
UnknownBicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity.
Not available
S-EPMC11571092 | biostudies-literature
UnknownBDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Not available
S-EPMC9589198 | biostudies-literature
UnknownMuscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.
Not available
S-EPMC5209746 | biostudies-literature
ProteomicsThe BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase
Strong associations exist between branched chain amino acids (BCAA) and dysregulated glucose and lipid metabolism, but the underlying mechanisms are not well understood. Here we report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulate branched-chain keto...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-18 | PXD009122 | Pride
Ppm1k Acl Bdk Protein phosphorylation Bcaa 
GenomicsRNA sequencing of red fruits of the Dongkui (DK) cultivar and the pink-white fruits of the Baidongkui (BDK) strain of Chinese bayberry
RNA sequencing of red fruits of the Dongkui (DK) cultivar and the pink-white fruits of the Baidongkui (BDK) strain of Chinese bayberry
PRJNA495037 | ENA
TranscriptomicsRestoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models
Patients with metabolic syndrome and heart failure (HF) often have accompanying kidney dysfunction, which was recently defined as cardiovascular-kidney-metabolic (CKM) syndrome. Prior metabolomics profiling of metabolic syndrome patients identified a plasma branched chain amino acid (BCAA) signature...
ORGANISM(S): Rattus norvegicus 
2025-06-01 | GSE263155 | GEO
UnknownEndurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism.
Not available
S-EPMC5515431 | biostudies-literature
UnknownStructure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
Not available
S-EPMC3683707 | biostudies-literature
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