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ProteomicsThe BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase
Strong associations exist between branched chain amino acids (BCAA) and dysregulated glucose and lipid metabolism, but the underlying mechanisms are not well understood. Here we report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulate branched-chain keto...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-18 | PXD009122 | Pride
Ppm1k Acl Bdk Protein phosphorylation Bcaa 
GenomicsThe expression of apoptosis related genes in HK-2 cells overexpressing PPM1K was determined by RNA-seq analysis
The expression of apoptosis related genes in HK-2 cells overexpressing PPM1K was determined by RNA-seq analysis
PRJNA876734 | ENA
UnknownPPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.
Not available
S-EPMC9986518 | biostudies-literature
TranscriptomicsSFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication
In this study, transcriptomic profiling identified PPM1K as a prominently induced host factor in SFTSV-infected THP-1 cells. We further demonstrate that SFTSV infection promotes endoplasmic reticulum–mitochondria coupling, enabling the viral glycoprotein GC to interact with mitochondrial PPM1K and e...
ORGANISM(S): Homo sapiens 
2026-04-21 | GSE328306 | GEO
GenomicsSFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication
SFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication
PRJNA1454527 | ENA
TranscriptomicsThe expression of apoptosis related genes in HK-2 cells overexpressing PPM1K was determined by RNA-seq analysis
To investigate the role of PPM1K in chronic kidney disease, we overexpressed PPM1K in human kidney-2 cells (HK-2). We then performed gene expression profiling analysis using data obtained from RNA-seq of 12 different cells.
ORGANISM(S): Homo sapiens 
2022-12-01 | GSE212681 | GEO
UnknownComprehensive Analysis of PPMs in Pancreatic Adenocarcinoma Indicates the Value of PPM1K in the Tumor Microenvironment.
Not available
S-EPMC9856814 | biostudies-literature
UnknownPPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons.
Not available
S-EPMC10522625 | biostudies-literature
UnknownEffects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.
Not available
S-EPMC8366658 | biostudies-literature
TranscriptomicsNervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory
To study the role of branched-chain amino acid metabolism in neural stem cells we generated two primary neural stem cell culture lines in which on was deleted for the Ppm1k gene using floxed cells and adenovirus delviered cre-recombinase.
ORGANISM(S): Mus musculus 
2023-04-06 | GSE205603 | GEO
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