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GenomicsDendritic Cell Fate is Determined by BCL11A
Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and for the first time demonstrate this lineage specific requirement in the adult organism. Genome-wide analyses of BCL11A DNA binding and expression revealed that BCL11A regulates transcription of...
ORGANISM(S): Homo sapiens 
2014-02-15 | E-GEOD-55043 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of human CD34-derived erythroid progenitors treated with BCL11A siRNAs
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the beta-thalassemia syndromes. Genetic association studies have identified sequence variants in the gene BCL11A that influence HbF levels. Here we examine BCL11A as a pote...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13284 | biostudies-arrayexpress
TranscriptomicsExpression data from BCL11A-null and wild-type bone marrow erythroid pregenitors
BCL11A is a critical mediator of hemoglobin switching and gamma-globin silencing. In this study, we showed the BCL11A is required in vivo for developmental silencing of gamma-globin genes in adult animals. We used microarray to determine the changes in gene expression profile after loss of BCL11A in...
ORGANISM(S): Mus musculus 
2012-03-22 | E-GEOD-28333 | biostudies-arrayexpress
TranscriptomicsBcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo
Bcl11a is a transcription factor known to regulate lymphoid and erythroid development. Recent bioinformatic analysis of global gene expression patterns has suggested a role for Bcl11a in the development of dendritic cell (DC) lineages. We tested this hypothesis by analyzing the development of DC and...
ORGANISM(S): Mus musculus 
2013-05-06 | E-GEOD-46270 | biostudies-arrayexpress
TranscriptomicsBCL11A: A Novel Breast Cancer Gene which Plays a Critical Role in Mammary Stem Cells and Progenitors
Triple negative breast cancer (TNBC) has poor prognostic outcome compared to other types of breast cancer1. At present the molecular and cellular mechanisms underlying TNBC pathology are not well understood1. Here we report that the transcription factor BCL11A is overexpressed in TNBC including b...
ORGANISM(S): Mus musculus 
2014-11-18 | E-GEOD-63386 | biostudies-arrayexpress
GenomicsChIP-Seq of BCL11A and SOX2 in lung squamous cell carcinoma (LUSC) LK-2 cell line with or without BCL11A knockdown
BCL11A is upregulated in lung squamous cell carcinoma (LUSC) but not in lung adenocarcinoma (LUAD). BCL11A interacts with SOX2 at protein level. ChIP-Seq experiment was performed for BCL11A and SOX2 in LUSC LK-2 control or BCL11A-KD cell line in order to identify their role in LUSC pathology.
ORGANISM(S): Homo sapiens 
2018-07-05 | E-MTAB-6958 | biostudies-arrayexpress
ProteomicsTemporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Reactivation of fetal hemoglobin expression by down-regulation of BCL11A is a promising treatment of -hemoglobinopathies. A detailed understanding of BCL11A-mediated repression of -globin gene (HBG1/2) transcription is lacking, as studies to date used perturbations by shRNA or CRISPR/Cas9 gene editi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-27 | PXD030301 | Pride
Dtag Protac Bcl11a Degradation 
ProteomicsTemporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Reactivation of fetal hemoglobin expression by down-regulation of BCL11A is a promising treatment of -hemoglobinopathies. A detailed understanding of BCL11A-mediated repression of -globin gene (HBG1/2) transcription is lacking, as studies to date used perturbations by shRNA or CRISPR/Cas9 gene editi...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD030307 | Pride
Proteomics Data-independent acqusition Protac Mass spectrometry Bcl11a Hemoglobinopathies 
GenomicsIdentification of BCL11A targets by CHIP Seq
We have recently identified BCL11A as a key regulator of mammary stem (MaSC) and progenitor cells. Deletion of BCL11A in MaSC leads to loss of ability of those cells to engraft a cleared mammary fatpad. This biological function of BCL11A correlates with its overexpression in basal breast cancers whi...
ORGANISM(S): Mus musculus 
2013-01-28 | E-ERAD-69 | biostudies-arrayexpress
TranscriptomicsDendritic cell fate is determined by BCL11A
The plasmacytoid dendritic cell (pDC) is vital to the coordinated action of innate and adaptive immunity. pDC development has not been unequivocally traced, nor has its transcriptional regulatory network been fully clarified. Here we confirm an essential requirement for the BCL11A transcription fact...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-55237 | biostudies-arrayexpress
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