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ProteomicsRepurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis
Acute pancreatitis (AP), a severe inflammatory disorder of the pancreas, lacks effective pharmacological treatment. The disease is primarily driven by necrosis of pancreatic acinar cells (PACs), which intensifies inflammation and organ injury. This study explores the potential of BCL2 inhibitors, sp...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD064881 | Pride
Pancreas Bcl2 inhibitors Venetoclax Pancreatitis Abt-199 Calcium signaling Fibrosis Abt-263 Necrosis Navitoclax Apoptosis 
GenomicsCombinatorial targeting of MYC/BCL2 double-hit lymphoma with mitochondrial complex I and BCL2 inhibitors
Combinatorial targeting of MYC/BCL2 double-hit lymphoma with mitochondrial complex I and BCL2 inhibitors
PRJNA627237 | ENA
TranscriptomicsInhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 [miRNA expression]
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and different...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-46375 | biostudies-arrayexpress
TranscriptomicsInhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 [Gene expression]
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and different...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-46374 | biostudies-arrayexpress
TranscriptomicsMCL1 inhibitor induces apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma
Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignanices and contributes to leukemogenesis by inhibiting the apoptotic machinery of the cells. BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leuke...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10903 | biostudies-arrayexpress
Genomicsm6a and NuRD complexes regulate monocytic differentiation and resistance to BCL2/BCL2L1 inhibitors in AML
m6a and NuRD complexes regulate monocytic differentiation and resistance to BCL2/BCL2L1 inhibitors in AML
PRJNA1248856 | ENA
GenomicsImmune profiling in mice treated with BCL2 or JAK1/2 inhibitors
Immune profiling in mice treated with BCL2 or JAK1/2 inhibitors
PRJNA750486 | ENA
TranscriptomicsCombinatorial targeting of MYC/BCL2 double-hit lymphoma with mitochondrial complex I and BCL2 inhibitors
Activation of the MYC oncogene is common in B-cell lymphomas, and frequently associated with compensatory events that dampen Myc-induced apoptosis, such as over-expression of anti-apoptotic Bcl2-family proteins. For example, concurrent translocations of MYC and BCL2 in a subset of Diffuse large B-ce...
ORGANISM(S): Mus musculus 
2022-03-01 | GSE149073 | GEO
UnknownComputational study on novel natural inhibitors targeting BCL2.
Not available
S-EPMC8280014 | biostudies-literature
GenomicsCEBPβ/IL-1β/TNFα Feedback Loop Drives Drug Resistance to BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells
CEBPβ/IL-1β/TNFα Feedback Loop Drives Drug Resistance to BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells
PRJNA1029043 | ENA
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