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TranscriptomicsThe BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers
Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. RNAseq was performed in endogeno...
ORGANISM(S): Homo sapiens 
2014-09-14 | E-GEOD-58365 | biostudies-arrayexpress
ProteomicsImmediate adaption – Quantitative Proteomics of BCL6 silencing and EGFR TK inhibition
We aimed to identify the response mechanism to EGFR tyrosine kinase inhibition. A431 cells were transfected with mock siRNA or BCL6 siRNA. Cells were then treated with gefitinib. Harvesting was done at 0h, at 24h and at 48h. Two TMT10plex sets were organized as follows: TMT set1: mock 0h (3x, channe...
ORGANISM(S): Homo sapiens (Human) 
2020-12-09 | PXD016605 | Pride
Human Bcl6 sirna Tmt proteomics Lc-ms Time course Egfr inhibition Gefitinib A431 cells 
UnknowniRGD-modified exosomes-delivered BCL6 siRNA inhibit the progression of diffuse large B-cell lymphoma.
Not available
S-EPMC9378967 | biostudies-literature
TranscriptomicsKnock-down of BCL6 expression in human Diffuse Large B-Cell Lymphoma cell lines
This dataset was used to benchmark the Virtual Inference of Protein-activity by Regulon Readout algorithm (VIPER). Despite recent advances in molecular profiling, proteome-wide assessment of protein activity in individual samples remains a highly elusive target. In stark contrast, protein activity q...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-45838 | biostudies-arrayexpress
GenomicsA biochemical basis for toggling enhancers from the active to poised state in B cells
BCL6 is crucial for B-cell activation and lymphomagenesis. We used integrative genomics to explore BCL6 mechanism in normal and malignant B-cells. Surprisingly, BCL6 assembled distinct complexes at enhancers vs. promoters. At enhancers BCL6 preferentially recruited SMRT, which mediated H3K27 deacety...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-29282 | biostudies-arrayexpress
GenomicsBCL6 mediates Chemoresistance in Acute Myeloid Leukemia
BCL6 mediates Chemoresistance in Acute Myeloid Leukemia
PRJNA549958 | ENA
GenomicsGenome wide binding of BCL6 and LSD1 In GC derived lymphoma B cells
Genome wide binding of BCL6 and LSD1 In GC derived lymphoma B cells
PRJNA421938 | ENA
TranscriptomicsTherapeutic targeting of GCB- and ABC-DLBCLs by rationally designed BCL6 inhibitors
BCL6 inhibitor induces derepression of BCL6 target genes and shows a similar transcriptional program to BCL6 siRNA
ORGANISM(S): Homo sapiens 
2016-10-13 | GSE79888 | GEO
GenomicsGenome wide binding of BCL6 and LSD1 In GC derived lymphoma B cells
Using ChIP-seq we identified the genome wide targets of BCL6 and LSD1 in lymhpoma cells (OCI-Ly1) with control siRNA or siRNA targeted to BCL6
ORGANISM(S): Homo sapiens 
2018-12-12 | GSE107920 | GEO
TranscriptomicsBCL6 mediates Chemoresistance in Acute Myeloid Leukemia
BCL6 is a transcription repressor that plays a crucial role in germinal center formation and lymphomagenesis. However, its role in myeloid malignancies remains unclear. Here, we explored the role of BCL6 in acute myeloid leukemia (AML). Heterogeneous levels of BCL6 were found across AML cell lines a...
ORGANISM(S): Homo sapiens 
2020-08-01 | GSE133112 | GEO
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