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ProteomicsFrequent mutations on amino-terminal BCL7A domain compromise its tumor suppressor role in DLBCL.
Mutations in genes encoding the various subunits of the SWI/SNF chromatin remodeling complex are frequently observed in different human cancers. In diffuse large B-cell lymphoma (DLBCL), genetic changes in BCL7A, a subunit of the SWI/SNF complex, have been recently reported but the functional role o...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD014795 | Pride
Bcl7a Swi/snf Dlbcl 
ProteomicsBCL7A’s Arginine Anchor Links Nucleosome Recognition to Chromatin Remodeling and DLBCL Tumor Suppression
The N-terminal α-helix of BCL7A, a non-catalytic subunit, exhibits characteristic positive charge distribution. To delineate its contribution to chromatin remodeling and gene regulation, we engineered an N-terminal deletion and performed functional comparisons with wild-type BCL7A in chromatin remod...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD064944 | Pride
Cbaf Human swi/snf Chromatin remodeling complex Bcl7a 
GenomicsRNA-seq Analysis of 14-day-old WT, bcl7a(brip3), bcl7b(brip4), bcl7a bcl7b(brip3 brip4), bcl7a bcl7b brm-3(brip3 brip4 brm-3) and bcl7a bcl7b brm-1(brip3 brip4 brm-1) seedlings under short day condition
RNA-seq Analysis of 14-day-old WT, bcl7a(brip3), bcl7b(brip4), bcl7a bcl7b(brip3 brip4), bcl7a bcl7b brm-3(brip3 brip4 brm-3) and bcl7a bcl7b brm-1(brip3 brip4 brm-1) seedlings under short day condition
PRJNA889000 | ENA
GenomicsBCL7A is silenced by hypermethylation to promote acute myeloid leukemia
BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
PRJNA940796 | ENA
UnknownStructure of the nucleosome-bound human BCL7A.
Not available
S-EPMC11983133 | biostudies-literature
TranscriptomicsRNA-seq Analysis of 14-day-old WT, bcl7a(brip3), bcl7b(brip4), bcl7a bcl7b(brip3 brip4), bcl7a bcl7b brm-3(brip3 brip4 brm-3) and bcl7a bcl7b brm-1(brip3 brip4 brm-1) seedlings under short day condition
Purpose：Examination of global gene expression of 14-day-old WT, bcl7a(brip3), bcl7b(brip4), bcl7a bcl7b(brip3 brip4), bcl7a bcl7b brm-3(brip3 brip4 brm-3) and bcl7a bcl7b brm-1(brip3 brip4 brm-1) seedlings under short day condition. Methods: Total RNA was extracted from 14-day-old Arabidopsis seedli...
ORGANISM(S): Arabidopsis thaliana 
2024-01-03 | GSE215151 | GEO
UnknownBCL7A is silenced by hypermethylation to promote acute myeloid leukemia.
Not available
S-EPMC10026484 | biostudies-literature
UnknownBCL7A as a novel prognostic biomarker for glioma patients.
Not available
S-EPMC8348860 | biostudies-literature
GenomicsLoss of BCL7A Permits IRF4 Transcriptional Activity and Cellular Growth in Multiple Myeloma
Loss of BCL7A Permits IRF4 Transcriptional Activity and Cellular Growth in Multiple Myeloma
PRJNA1206222 | ENA
UnknownBCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
Not available
S-EPMC9713712 | biostudies-literature
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