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ProteomicsPhosphoproteome of MCF7 breast cancer cells treated with estradiol and BI2536
Triple SILAC phosphoproteome experiment of hormone deprived MCF7 cells treated with estradiol (E2) in presence or absence of the PLK1 inhibitor BI2536. Conditions were as follows: light (L) population: 1h DMSO, 30min EtOH; medium (M) population: 1h DMSO, 30min E2; heavy (H) population: 1h BI2536, 3...
ORGANISM(S): Homo sapiens (Human) 
2016-06-24 | PXD000275 | Pride
Mcf7 Silac Phosphorylation Gene regulation Plk1 Phosphoproteomics Bi2536 Estradiol 
ProteomicsTFIIIC dinamically binds Alu elements to control gene expression through chromatin looping
Folding of the mammalian genome is governed by architectural proteins, such asCTCF. TFIIIC, a RNA polymerase III transcription factor, has been identified as aninsulator but its role in genome topology is totally unknown. Here, we show that TFIIICestablishes long-range genomic interactions that affe...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD011250 | Pride
Human Breast cancer Alu Tfiiic 
TranscriptomicsDistinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation
The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3CM-bM-^@M-^Sderived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-53463 | biostudies-arrayexpress
TranscriptomicsNucleosome driven transcription factor binding and gene regulati
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41617 | biostudies-arrayexpress
TranscriptomicsNucleosome driven transcription factor binding and gene regulation [microarray]
Elucidating the global function of a transcription factor implies the identification of its target genes and genomic binding sites. The role of chromatin in this context is unclear, but the dominant view is that factors bind preferentially to nucleosome-depleted regions, identified as DNaseI-hyperse...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41502 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by the pan-PIM inhibitor ETP-39010 in 4 peripheral T cell lymphoma cell lines
Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. In these study we hypothesized that PIM kinases could be of therapeutic value in PTCL because we ...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-42595 | biostudies-arrayexpress
UnknownEffects of submaximal and supramaximal accentuated eccentric loading on mass and function.
Not available
S-EPMC10337133 | biostudies-literature
GenomicsNucleosome density map during B-cell to Macrophage lineage switching
Using homogenous populations of cells undergoing lineage switching we studied enhancer nucleation related to nucleosme organization. Examination of nucleosome densities by using Mnase-seq at several time points after induction of lineage switching
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-53460 | biostudies-arrayexpress
UnknownEarly Lopinavir/ritonavir does not reduce mortality in COVID-19 patients: Results of a large multicenter study.
Not available
S-EPMC7877892 | biostudies-literature
TranscriptomicsGene-expression profile in a series of non-Hodgkin lymphoma (NHL) patients
PIM serine/threonine kinases are overexpressed, translocated or amplified in multiple B-cell lymphoma types. We have explored the frequency and relevance of PIM expression in different B-cell lymphoma types, and investigated whether PIM inhibition could be a rational therapeutic approach. Increased ...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-32018 | biostudies-arrayexpress
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