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ProteomicsPhosphoproteome of MCF7 breast cancer cells treated with estradiol and BI2536
Triple SILAC phosphoproteome experiment of hormone deprived MCF7 cells treated with estradiol (E2) in presence or absence of the PLK1 inhibitor BI2536. Conditions were as follows: light (L) population: 1h DMSO, 30min EtOH; medium (M) population: 1h DMSO, 30min E2; heavy (H) population: 1h BI2536, 3...
ORGANISM(S): Homo sapiens (Human) 
2016-06-24 | PXD000275 | Pride
Mcf7 Silac Phosphorylation Gene regulation Plk1 Phosphoproteomics Bi2536 Estradiol 
UnknownBI2536 induces mitotic catastrophe and radiosensitization in human oral cancer cells.
Not available
S-EPMC5940398 | biostudies-literature
TranscriptomicsPLK1 signaling coopereates with estrogen receptor-dependent gene transcription.
Analysis of MCF7 breast cancer cells treated with estadiol for 6 h in presence or absence of the specific PLK1 inhibitor BI2536. Together with CHIP and global phosphoproteome data, the results demonstrate a key role of PLK1 in the estrogen receptor-mediated gene response. Hormone-deprived MCF7 cells...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-46856 | biostudies-arrayexpress
UnknownInhibition of Polo kinase by BI2536 affects centriole separation during Drosophila male meiosis.
Not available
S-EPMC4111698 | biostudies-literature
UnknownPolo‑like kinase 1 selective inhibitor BI2536 (dihydropteridinone) disrupts centrosome homeostasis via ATM‑ERK cascade in adrenocortical carcinoma.
Not available
S-EPMC10394735 | biostudies-literature
TranscriptomicsExpression data from BMDCs treated with BI2536 or vehicle control and stimulated with LPS or poly(I:C)
We used microarrays to detail the global programme of gene expression underlying Polo-like kinase inhibition with BI 2536 compound in mouse bone marrow-derived dendritic cells (BMDCs) stimulated with Toll-like receptor agonists LPS and poly(I:C). CD11c+ BMDCs were treated for 1 hour with BI 2536 (1µ...
ORGANISM(S): Mus musculus 
2011-04-12 | E-GEOD-28520 | biostudies-arrayexpress
UnknownPlk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission
Not available
S-JCBD-201008108 | bioimages
TranscriptomicsPLK1 signaling coopereates with estrogen receptor-dependent gene transcription.
Analysis of MCF7 breast cancer cells treated with estadiol for 6 h in presence or absence of the specific PLK1 inhibitor BI2536. Together with CHIP and global phosphoproteome data, the results demonstrate a key role of PLK1 in the estrogen receptor-mediated gene response.
ORGANISM(S): Homo sapiens 
2014-01-01 | GSE46856 | GEO
UnknownA PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma.
Not available
S-EPMC6442225 | biostudies-literature
UnknownNavitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems.
Not available
S-EPMC9229367 | biostudies-literature
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