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ProteomicsLocalization of the priming factors CAPS1 and CAPS2 in mouse sensory neurons is determined by their N-termini
Both paralogs of the calcium-dependent activator protein for secretion (CAPS) are required for exocytosis of synaptic vesicles (SVs) and large dense core vesicles (LDCVs). Despite approximately 80% sequence identity, CAPS1 and CAPS2 have distinct functions in promoting exocytosis of SVs and LDCVs in...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-01 | PXD031625 | Pride
Synapse Active zone Nano lc ms Intracellular trafficking Dorsal root ganglion Cellular localization 
ProteomicsT-cell derived exosomes released from Multi-Core Granules exhibit potent caspase 3 mediated tumor suppressive activity ( Part II)
Small extracellular vesicles (sEV) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity, yet their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potenti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD070419 | Pride
Tetraspanins 10x-expansion Munc13-4 Extracellular vesicles Primary cells Cd8+ t-cells Immunological synapse Multivesicular bodies 
ProteomicsT-cell derived exosomes released from Multi-Core Granules exhibit potent caspase 3 mediated tumor suppressive activity
Small extracellular vesicles (sEV) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity, yet their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potenti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD064012 | Pride
Tetraspanins 10x-expansion Munc13-4 Extracellular vesicles Primary cells Cd8+ t-cells Immunological synapse Multivesicular bodies 
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