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ProteomicsWhole cell iTRAQ proteome analysis of 4T1 cells (control and Munc13-4 KO)
We identified differentially expressed proteins in the proteomes of control and Munc13-4 knockout 4T1 cells, and conducted enrichment analysis based on the KEGG database to pinpoint relevant cellular processes and organismal systems affected by Munc13-4 knockout.
ORGANISM(S): Mus musculus (Mouse) 
2025-09-19 | PXD059882 | Pride
Breast cancer Munc13-4 4t1 cells 
UnknownThe Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.
Not available
S-EPMC6363534 | biostudies-literature
UnknownA novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.
Not available
S-EPMC5469611 | biostudies-literature
UnknownA Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4.
Not available
S-EPMC6080937 | biostudies-literature
UnknownMast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37.
Not available
S-EPMC4773767 | biostudies-literature
UnknownMunc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils.
Not available
S-EPMC3037678 | biostudies-literature
UnknownMunc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses.
Not available
S-EPMC4751605 | biostudies-literature
UnknownMunc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.
Not available
S-EPMC2924225 | biostudies-literature
UnknownMunc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes.
Not available
S-EPMC12518824 | biostudies-literature
UnknownNovel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis.
Not available
S-EPMC2563207 | biostudies-literature
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