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GenomicsMethylome Analysis of FF HPV+ and HPV- HNSCC samples
The analysis of the 6 methylomes by MeDIP-Seq comprise 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples Analysis of the 6 methylomes, comprising 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-38263 | biostudies-arrayexpress
TranscriptomicsA Comparison of HEEBO Microarray and 3'-end Sequencing for Expression Quantification (3SEQ) (Archival Tumor Samples)
Gene expression microarrays are the most widely used technique for genome-wide expression profiling. However, microarrays do not perform well on formalin fixed paraffin embedded tissue (FFPET). Consequently, microarrays cannot be effectively utilized to perform gene expression profiling on the vast ...
ORGANISM(S): Homo sapiens 
2010-03-25 | E-GEOD-18209 | biostudies-arrayexpress
TranscriptomicsIntegrative Molecular Profiling in Leiomyosarcoma
Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We employed integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering dem...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-17555 | biostudies-arrayexpress
TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
ProteomicsProteomics of rat neonatal cardiac fibroblasts
Gβγ subunits are involved in many different signalling processes in various compartments of the cell, including the nucleus. To gain insight into the functions of nuclear Gβγ, we investigated the functional role of Gβγ signalling in regulation of GPCR-mediated gene expression in primary rat neonatal...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD025993 | Pride
Gnb1 Rat cardiac fibroblasts Angiotensin ii Bottom-up proteomics 
GenomicsComparative methylome analysis of benign and malignant peripheral nerve sheath tumors
Aberrant DNA methylation (DNAm) was first linked to cancer over 25 years ago. Since then, many studies have associated hypermethylation of tumour suppressor genes and hypomethylation of oncogenes to the tumourigenic process. However, most of these studies have been limited to the analysis of promote...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21714 | biostudies-arrayexpress
TranscriptomicsHumanMethylation450 (450k) data for 79 rheumatoid arthritis disease discordant monozygotic twin pairs
This project contains genome-wide DNA methylation data generated using the HumanMethylation450 BeadChip (Illumina), for 79 rheumatoid arthritis (RA) discordant monozygotic twin pairs. By investigating disease discordant monozygotic twins, DNA methylation can be assessed without the confounding influ...
ORGANISM(S): Homo sapiens 
2018-07-24 | E-MTAB-6988 | biostudies-arrayexpress
UnknownA pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution.
Not available
S-EPMC8916958 | biostudies-literature
TranscriptomicsExpression profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Gene expression profiling was performed in comparison to normal neural stem (NS) cells reprogrammed in parallel, as well as standard ES cells as an indepe...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1273 | biostudies-arrayexpress
Transcriptomics450k Analysis of 24 HNSCC cell lines
The methylation analysis of HPV+ HNSCC cell lines and HPV- HNSCC cell lines as well as clones from an infected HPV- cell line by Infinium HumanMethylation450 BeadChip Analysis of 24 450k methylation profiles, comprising 3 HPV+ HNSCC cell lines and 3 HPV- HNSCC cell lines (in duplicate each) and 12 i...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-38270 | biostudies-arrayexpress
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