Sort   by:  
 Page size 
ProteomicsProteomic analysis of renal biomarkers of kidney allograft fibrosis – a study in renal transplant patients
Renal transplantation is the preferred treatment of end stage renal disease, but allograft survival is limited by development of interstitial fibrosis and tubular atrophy in response to various stimuli. Much effort has been put into identifying new protein markers of fibrosis to support the diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD017867 | Pride
Nano-lc-msms Transplant Kidney fibrosis 
ProteomicsSpectral Library Search for Improved TMTpro Labelled Peptide Assignment in Human Plasma Proteomics
Clinical biomarker discovery is often based on the analysis of human plasma samples. However, the high dynamic range and complexity of plasma pose significant challenges to mass spectrometry-based proteomics. Current methods for improving protein identifications require laborious pre-analytical samp...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042546 | Pride
Peptide identification  plasma proteomics  spectral library search  tmtpro 
ProteomicsNicotine administration augments abdominal aortic aneurysm progression in rats
Inflammation and elastin degradation are key hallmarks in the pathogenesis of abdominal aortic aneurysms (AAA). It has been acknowledged that activation of alpha7 nicotinic acetylcholine receptors (α7nAChRs) attenuates inflammation, termed the cholinergic anti-inflammatory pathway (CAP). Thus, we hy...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD040414 | Pride
Therapeutic strategy Inflammation Aortic aneurysm Proteomics Alpha7 nicotinic acetylcholine receptor Vascular remodeling Nicotine Animal model 
ProteomicsPKC Inhibition by GÖ6976 Promotes Osteogenic Differentiation of Dental Follicle Cells via Activation of RhoA GTPase Signaling
Dental follicle cells (DFCs) are promising candidates for regenerative medicine due to their osteogenic potential. While the protein kinase C (PKC) inhibitor Gö6976 is known to enhance DFC differentiation, the underlying molecular mechanisms remain partially understood. Methods: We performed a pho...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD081715 | Pride
Dental follicle cells  osteogenesis  protein kinase c  rhogtpase  sost  phosphoproteomics 
ProteomicsAffinity capture enrichment versus Affinity depletion: A comparison of strategies for increasing coverage of low abundant human plasma proteins
present study, we evaluated four small molecule affinity-based probes based on agarose-immobilized benzamidine (ABA), O-Phospho-L-Tyrosine (pTYR), 8-Amino-hexyl-cAMP (cAMP), or 8-Amino-hexyl-ATP (ATP) for their ability to remove high-abundant proteins such as serum albumin from plasma samples thereb...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD020727 | Pride
Affinity enrichment Depletion Human plasma 
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort1
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008467 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsPlasma proteomics reveals the confounding effect of heparin administration on the analysis of candidate cardiovascular biomarkers - Cohort2
Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. One reason may relate to interference of medication on plasma protein levels. In the present study we applied a proteomic approach to identify plasma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008468 | Pride
Heparin Chemi-proteomics Cardiovascular biomkarkers 
ProteomicsSelective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression
Tumor necrosis factor (TNF) is elevated in human abdominal aortic aneurysms (AAA). Non-selective TNF inhibition has been linked to several severe side effects. Compounds that target the proinflammatory soluble TNF (solTNF) while preserving the immunomodulatory capabilities of transmembrane TNF (tmTN...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD035178 | Pride
Mouse abdominal aorta aneurysm 
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-20 | PXD002214 | Pride
Type 2 diabetes artery proteomics 
ProteomicsCD31 defines a subpopulation of human adipose-derived regenerative cells with potent angiogenic properties
A major challenge in realizing regenerative treatment using freshly isolated Adipose Derived Regenerative Cells (ADRCs) is the cellular heterogeneity and donor variability. Ex vivo expanded ADRCs (=ASCs) are available at larger quantities and represent a more homogeneous population suitable for allo...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040388 | Pride
Cd31 Proteomics Regenerative cells 
Sort   by:  
 Page size