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GenomicsCondensin association with chromosomes depends on a DNA binding domain formed by its HEAT-repeat subunits
Condensin protein complexes play central roles in the three-dimensional organization of chromosomes during mitotic and meiotic cell divisions. How condensin interacts with its chromatin substrates to promote sister chromatid decatenation and segregation is largely unknown. Previous work suggested th...
ORGANISM(S): Saccharomyces cerevisiae 
2014-05-16 | E-GEOD-55948 | biostudies-arrayexpress
ProteomicsHistone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins
Histone deacetylases (HDACs) and acetyltransferases control the epigenetic regulation of gene expression through modification of histone marks. Histone deacetylase inhibitors (HDACi) are small molecules that interfere with histone tail modification thus altering chromatin structure and epigeneticall...
ORGANISM(S): Homo sapiens (Human) 
2015-03-18 | PXD001660 | Pride
Gene expression Bromodomain Nucleus Hdaci Lc-ms/ms 
UnknownUrea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression.
Not available
S-EPMC3352965 | biostudies-literature
ProteomicsSubcellular proteomics of murine presomitic mesoderm
We studied the effects of different stimuli on on the subcellular proteome of primary murine presomitic mesoderm tissue (PSM) in two separate experiments. In the first experiment, tissue was treated ex vivo with either fructose-6-phosphate, fructose-1,6-bisphosphate, or control treatment before subc...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD029988 | Pride
Fructose-1 Subcellular proteomics Tmt Presomitic mesoderm 6-bisphosphate Fructose-6-phosphate Glycolysis Subcellular fractionation Lc-ms/ms 
ProteomicsIntegrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old an...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-10-05 | PXD002467 | Pride
Brain Rat Liver Aging 
ProteomicsSpatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma
The inter-patient variability of tumor proteomes has been investigated on a large scale but many tumors display also intra-tumoral heterogeneity (ITH) regarding morphological and genetic features. To what extent the local proteome of tumors intrinsically differs remains largely unknown. Here, we use...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-24 | PXD007052 | Pride
Intra-tumoral heterogeneity Liver Hepatocellular carcinoma 
ProteomicsPre-assembled Nuclear Pores Insert into the Nuclear Envelope During Early Development
Nuclear Pore Complexes (NPCs) span the nuclear envelope (NE) and mediate nucleocytoplasmic transport. In metazoan oocytes and early embryos, NPCs not only reside within the NE but also at some endoplasmatic reticulum (ER) membrane sheets, termed annulate lamellae (AL). Although a role for AL as NPC ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-07-12 | PXD004120 | Pride
Lc-ms/ms Subcellular fractionation Drosophila melanogaster 
ProteomicsLandscape of nuclear transport receptor cargo specificity
Nuclear transport receptors (NTRs) recognize localization signals of cargos to facilitate their passage across the central channel of nuclear pore complexes (NPCs). About 30 different NTRs constitute different transport pathways in humans and bind to a multitude of different cargos. The exact cargo ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-14 | PXD007976 | Pride
Proximity ligation Interaction network Protein transport Proteomics Nuclear pore complex 
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080848 | MassIVE
ProteomicsCapturing protein communities by structural proteomics in a thermophilic eukaryote
The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive. Here, we show that crude cellular extracts of a eukaryot...
ORGANISM(S): Chaetomium thermophilum 
2017-08-07 | PXD006660 | Pride
Xl-ms Protein communities Chaetomium thermophilum 
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