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ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
UnknownEpigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.
Not available
S-EPMC3918538 | biostudies-literature
TranscriptomicsExpression data from colon epithelium of STAT3IEC-KO in acute DSS colitis
STAT3 is a pleiotropic transcription factor with important functions in cytokine signalling in a variety of tissues. However, the role of STAT3 in the intestinal epithelium is not well understood. Here we demonstrate that development of colonic inflammation is associated with the induction of STAT3...
ORGANISM(S): Mus musculus 
2009-05-08 | E-GEOD-15955 | biostudies-arrayexpress
TranscriptomicsEffects of caspase-8 deletion in the intestinal epithelium
Caspase-8 is a cystein protease involved in regulating apoptosis. The function of caspase-8 was studied in the intestinal epithelium, using mice with an intestinal epithelial cell specific deletion of caspase-8. We used microarrays to investigate the difference of the global programme of gene expres...
ORGANISM(S): Mus musculus 
2011-07-22 | E-GEOD-30873 | biostudies-arrayexpress
TranscriptomicsAdaptation of Bacillus subtilis carbon core metabolism to simultaneous nutrient limitation and osmotic challenge
Here, we investigated for the first time the systems-wide response of B. subtilis to different simultaneous stresses, i.e. nutrient limitation and high osmolarity. To address the anticipated complexity of the cellular response networks, we combined chemostat experiments under conditions of carbon li...
ORGANISM(S): Bacillus subtilis 
2014-03-31 | E-GEOD-53333 | biostudies-arrayexpress
TranscriptomicsEimeria vermiformis infection mouse model
Part of a mouse inflammation model set in order to observe the similarities and differences between the multiple options for the generation of intestinal inflammation in an animal model. Experimental samples are generated according to the standard protocol for the model. and are processes using the ...
ORGANISM(S): Mus musculus 
2025-01-30 | E-MTAB-14297 | biostudies-arrayexpress
TranscriptomicsAcute and chronic DSS mouse models; T cell transfer colitis model
Part of a mouse inflammation model set in order to observe the similarities and differences between the multiple options for the generation of intestinal inflammation in an animal model. Experimental samples are generated according to the standard protocol for the model and are processes using the s...
ORGANISM(S): Mus musculus 
2025-01-30 | E-MTAB-14306 | biostudies-arrayexpress
TranscriptomicsOxazolone colitis and Citrobacter rodentium infection models
Part of a mouse inflammation model set in order to observe the similarities and differences between the multiple options for the generation of intestinal inflammation in an animal model. Experimental samples are generated according to the standard protocol for the model. and are processes using the ...
ORGANISM(S): Mus musculus 
2025-01-30 | E-MTAB-14312 | biostudies-arrayexpress
TranscriptomicsHelicobacter hepaticus infection model
Part of a mouse inflammation model set in order to observe the similarities and differences between the multiple options for the generation of intestinal inflammation in an animal model. Experimental samples are generated according to the standard protocol for the model. and are processes using the ...
ORGANISM(S): Mus musculus 
2025-01-30 | E-MTAB-14316 | biostudies-arrayexpress
TranscriptomicsIntestinal epithelial cell Caspase 8 ablation colitis and ileitis
Part of a mouse inflammation model set in order to observe the similarities and differences between the multiple options for the generation of intestinal inflammation in an animal model. Experimental samples are generated according to the standard protocol for the model. and are processes using the ...
ORGANISM(S): Mus musculus 
2025-01-30 | E-MTAB-14318 | biostudies-arrayexpress
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