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ProteomicsMitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol - Data Set 2: Hsp104 AP-MS
Hundreds of mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational reaction. The early stages in mitochondrial protein targeting are poorly understood. Here we show that in baker’s yeast, the cytosol has the capacity to transiently stor...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD035762 | Pride
Mitostores Mitochondrial import Hsp104 
ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex - DATA SET II
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD036508 | Pride
Mitochondrial import Ubc8 Yeast metabolism 
ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD033171 | Pride
Mitochondrial import Metabolic switch 
ProteomicsProteomic landscape of human spermatozoa in patients with different spermatogenic impairments
Infertility is a widespread problem, affecting around 15% of couples worldwide, and is defined as the inability to achieve pregnancy within one year despite unprotected intercourse 1. Infertility can be caused by either male or female reproductive issues. Various medical conditions including maligna...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-05-10 | PXD039703 | Pride
Sperm Infertility 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 1
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD049120 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 2
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD049124 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 3
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD056432 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
TranscriptomicsRibo-Seq of UPF1 depletion in human colorectal adenocarcinoma cell line HCT116 via the auxin-inducible degron (AID) system
UPF1 is a multi-domain RNA helicase that constantly monitors the transcriptome by non-specifically binding to mRNAs, dissociating from non-target transcripts, and initiating degradation on selected target RNAs via multiple proposed pathways such as nonsense-mediated decay (NMD). NMD is a translation...
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-13837 | biostudies-arrayexpress
TranscriptomicsSLAM-Seq of UPF1 depletion in human colorectal adenocarcinoma cell line HCT116 via the auxin-inducible degron (AID) system
UPF1 is a multi-domain RNA helicase that constantly monitors the transcriptome by non-specifically binding to mRNAs, dissociating from non-target transcripts, and initiating degradation on selected target RNAs via multiple proposed pathways such as nonsense-mediated decay (NMD). NMD is a translation...
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-13836 | biostudies-arrayexpress
TranscriptomicsInitial Test-RNA-Seq of UPF1 depletion in human colorectal adenocarcinoma cell line HCT116 via the auxin-inducible degron (AID) system
UPF1 is a multi-domain RNA helicase that constantly monitors the transcriptome by non-specifically binding to mRNAs, dissociating from non-target transcripts, and initiating degradation on selected target RNAs via multiple proposed pathways such as nonsense-mediated decay (NMD). NMD is a translation...
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-13839 | biostudies-arrayexpress
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