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TranscriptomicsHost Age is a Systemic Regulator of Gene Expression Impacting Cancer Progression
Given that aging is the major determinant of cancer incidence, and that cancer incidence is dictated in large part by processes modulating progression of existing subclinical cancers, we demonstrate that aging may be an organizing axis for identifying cancer progression-modulating processes. This wo...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-66414 | biostudies-arrayexpress
TranscriptomicsProton irradiation augments the reduction in tumor progression observed with advanced age
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that, in addition to targeting advantages, proton irradiation can inhibit angiogenic and immune factors and thereby modulate tumor...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-45609 | biostudies-arrayexpress
TranscriptomicsAge and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data show that from adolescence through middle age, cancer incidence increases with age. This effect is commonly attributed to a lifetime a...
ORGANISM(S): Mus musculus 
2013-06-13 | E-GEOD-45606 | biostudies-arrayexpress
TranscriptomicsProton Irradiation Impacts Age Driven Modulations of Cancer Progression Influenced by Immune System Transcriptome Modifications from Splenic Tissue
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological modulations including inhibition of angiogenic and immune factors critical to “hallmark” processes impacting tumor development, in addi...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-67243 | biostudies-arrayexpress
TranscriptomicsTGFβ confers resistance to radiotherapy in non-small cell lung cancer
Radiotherapy is standard of care for inoperable non-small cell lung cancers (NSCLC) but adenocarcinoma NSCLC respond more poorly than squamous cell NSCLC. Transforming growth factor β (TGFβ) activity is induced by radiation and plays a recently recognized role in the DNA damage response. Here w...
ORGANISM(S): Mus musculus 
2015-12-15 | E-GEOD-73095 | biostudies-arrayexpress
TranscriptomicsMYC and CHK1 Dependent Cell Death in T-cell Lymphoma and Hodgkin Lymphoma Cell Lines and Human Xenograft Models Via Anti-Proteasomal Therapy (Illumina)
We examined the biological effects of a potent second-generation proteasome inhibitor, ixazomib, in T-cell lymphoma and Hodgkin lymphoma cell lines and human xenograft models. Ixazomib resulted in time- and dose-dependent cytotoxicity and apoptosis in all cell lines (IC50’s <75nM). In vivo studies v...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-66415 | biostudies-arrayexpress
TranscriptomicsMYC and CHK1 Dependent Cell Death in T-cell Lymphoma and Hodgkin Lymphoma Cell Lines and Human Xenograft Models Via Anti-Proteasomal Therapy (Affymetrix)
We examined the biological effects of a potent second-generation proteasome inhibitor, ixazomib, in T-cell lymphoma and Hodgkin lymphoma cell lines and human xenograft models. Ixazomib resulted in time- and dose-dependent cytotoxicity and apoptosis in all cell lines (IC50’s <75nM). In vivo studies v...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-66417 | biostudies-arrayexpress
UnknownSystem-wide transcriptome damage and tissue identity loss in COVID-19 patients.
Not available
S-EPMC8784611 | biostudies-literature
UnknownMolecular and physiological changes in the SpaceX Inspiration4 civilian crew.
Not available
S-EPMC11357997 | biostudies-literature
UnknownHealth in times of uncertainty in the eastern Mediterranean region, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Not available
S-EPMC6660972 | biostudies-literature
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