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GenomicsAdverse outcome pathways of ionizing radiation investigated with multi-omics and benchmark dose modeling
Adverse outcome pathways of ionizing radiation investigated with multi-omics and benchmark dose modeling
PRJNA1082296 | ENA
TranscriptomicsGene expression microarray analysis of rat nasal tissue with time and dose following formaldehyde inhalation
Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this study, concentration- and exposure-duration transitions in FA mode of action (MOA) were examined with pharmacokinetic (PK) modeling for tissue formaldehyde acetal (FAcetal) and glutathione (GSH) and with histopath...
ORGANISM(S): Rattus norvegicus 
2010-07-28 | E-GEOD-23179 | biostudies-arrayexpress
TranscriptomicsTranscriptional Biomarkers to Predict Female Mouse Liver Tumors in Rodent Cancer Bioassays - A 26 Chemical Set
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2010-03-08 | E-GEOD-18858 | biostudies-arrayexpress
UnknownSimple benchmark for complex dose finding studies.
Not available
S-EPMC4061271 | biostudies-literature
GenomicsTranscriptomic effects of tributyltin (TBT) in zebrafish eleutheroembryos. A functional benchmark dose analysis.
Transcriptomic effects of tributyltin (TBT) in zebrafish eleutheroembryos. A functional benchmark dose analysis.
PRJNA580463 | ENA
UnknownSemi-parametric benchmark dose analysis with monotone additive models.
Not available
S-EPMC11403299 | biostudies-literature
UnknownA benchmark for dose-finding studies with unknown ordering.
Not available
S-EPMC9291639 | biostudies-literature
GenomicsIdentifying suitable experimental designs to determining differentially expressed genes and benchmark doses from transcriptomic dose-response studies in zebrafish embryos
Identifying suitable experimental designs to determining differentially expressed genes and benchmark doses from transcriptomic dose-response studies in zebrafish embryos
PRJNA957853 | ENA
TranscriptomicsAdverse outcome pathways of ionizing radiation investigated with multi-omics and benchmark dose modeling
Background/Issue and Objectives: Health risks from chronic low dose radiation exposures encountered in environmental and occupational settings are uncertain. A key aspect to understanding health risks is precise and accurate modelling of the dose-response relationship. Benchmark dose (BMD) modeling ...
ORGANISM(S): Homo sapiens 
2025-02-28 | GSE260589 | GEO
ModelsMinimal dynamical thermal dose model - Ladjimi et al. 2019
The model provides a minimal mechanistic description of cellular survival under hyperthermia. Heat induces the production of misfolded proteins, which are either degraded or repaired by molecular chaperones. The repair process is saturable because chaperone resources are limited, causing misfolded p...
2026-09-02 | MODEL2608180004 | BioModels
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