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ProteomicsThe yeast peroxisomal proteome at absolute quantitative scale
Peroxisomes are dynamic organelles vital for lipid metabolism and redox homeostasis. In Saccharomyces cerevisiae, the expression of peroxisomal proteins is tightly regulated in response to metabolic conditions. Here, we provide the first absolute quantification of the yeast peroxisomal proteome unde...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-16 | PXD069526 | Pride
Saccharomyces cerevisiae  peroxisomes  protein copy numbers  absolute quantification  proteomic ruler  mass spectrometry 
ProteomicsSilencing mitochondrial gene expression in living cells – FLAG IPs
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061877 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Hek293t cells Gene expression Quantitative ap-ms Label-free Translation 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam16 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046840 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam18 SILAC RNAiTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam18 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046845 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsSilencing mitochondrial gene expression in living cells – CYTB- and ND2-KD data
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061846 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Quantitative mass spectrometry Hek293t cells Gene expression Label-free Translation 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – MaRF11 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD053251 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam16 CoIPs
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046849 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Affinity purification-mass spectrometry Silac Maxicircle replication 
ProteomicsPex39 facilitates peroxisomal import of PTS2 proteins – PEX39 KO SILAC data
Peroxisomes are metabolic organelles essential for human health. Defects in peroxisomal biogenesis proteins (peroxins/PEXs) cause devastating disease. PEX7 binds cargo proteins containing a type 2 peroxisomal targeting sequence (PTS2) to enable import of PTS2 proteins from the cytosol into peroxisom...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-07 | PXD051550 | Pride
Quantitative mass spectrometry Peroxisomes Silac Saccharomyces cerevisiae Peroxisomal matrix protein import Pts2 import Pex39 
ProteomicsAnalysis of ageing-dependent thiol oxidation reveals early oxidation of proteins involved in core proteostasis functions
Oxidants have a profound impact on biological systems in physiology and under pathological conditions. Oxidative post-translational modifications of protein thiols are well-recognized as a readily occurring alteration of proteins. Changes in protein thiol redox state can modify the function of prote...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-07 | PXD042047 | Pride
Yeast Oxicat Proteostasis Thiol oxidation 
ProteomicsRole of TbTim20 in mitochondrial protein import in trypanosomes – TbTim20 CoIPs
Protein import across the mitochondrial inner membrane typically depends on two protein translocases of the inner membrane (TIM) complexes and the membrane potential. The protozoan parasite Trypanosoma brucei, however, has a single, divergent TIM complex. Unlike other trypanosomal TIM subunits, TbTi...
ORGANISM(S): Trypanosoma brucei 
2025-10-27 | PXD061390 | Pride
Trypanosoma brucei Proteomics Affinity purification-mass spectrometry Mitochondrial genome Silac Mitochondrial protein import 
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