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TranscriptomicsTranscriptomic effects of long-term pantethine treatment in the mouse Alzheimer's disease 5XFAD model
Pantethine, an anti-cholesterol drug, was shown to inhibit the Ab (amyloid beta) peptide-induced expression of IL-1b in primary culture astrocytes derived from either untreated Ab-treated and untreated 5XFAD or Ab-treated WT. These observations prompted us to investigate the effects of pantethine at...
ORGANISM(S): Mus musculus 
2018-07-15 | E-MTAB-6772 | biostudies-arrayexpress
TranscriptomicsComparaison of APOE4 and APOE3 transcriptomic profiles from derived cell lines in absence or presence of an inflammatory stimulus
Our objective was to study some of the molecular changes that associate with APOE4, ultimately aiming at identifying new mechanisms that support exacerbated neuroinflammation as a cause of functional deterioration in Alzheimer's disease (AD). We hypothesize that the increased risk of developing AD i...
ORGANISM(S): Homo sapiens 
2021-02-01 | E-MTAB-9625 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain tissue from cerebral malaria-resistant and susceptible strains of mice in a time series following infection with Plasmodium berghei
Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (...
ORGANISM(S): Mus musculus 
2007-05-01 | E-MEXP-1018 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of the antiviral effect of chloroquine and derivatives on in vitro HCV infected cells.
The main goal of this study is to characterize the transcriptional modulations induced by antiviral compounds derived from chloroquine on Huh7 cells infected with HCV. And thus to identify among the genes modulated by infection, those who are regulated by chloroquine and potentially involved in the ...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-30351 | biostudies-arrayexpress
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