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ProteomicsAntagonistic regulation of apoptosis by polysulfides and thioredoxin via persulfidation of caspases
Hydrogen sulfide has been implicated in a large number of physiological processes including cell survival and death, encouraging research into its mechanisms of action and therapeutic potential. Recent studies suggest that the cellular effects of hydrogen sulfide are mediated in part by sulfane sulf...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD017144 | Pride
Thioredoxin Persulfidation Polysulfides Apoptosis Caspases 
ProteomicsA substrate trapping approach identifies proteins regulated by reversible S-nitrosylation
In this study we adapted the Trx trapping strategy for global profiling of cellular nitrosylation/denitrosylation processes. Using this approach, we report the identification of hundreds of potential new nitrosylated targets in monoctyes and macrophages followed by validation using biochemical and f...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-07-02 | PXD001001 | Pride
Proteomics Human S-nitrosylation 
ProteomicsWidespread cysteine persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress
A hallmark of immune-inflammatory responses is the generation of reactive oxygen and nitrogen species by innate immune cells, in particular macrophages. How macrophages cope with excess oxidant production and associated redox stress is not fully understood. Recent evidence implicates reactive sulfur...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD044043 | Pride
Oxidative-inflammatory stress Macrophages 
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