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ProteomicsNeuronal aging leads to disrupted RNA metabolism
Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged (i.e. >50 yea...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD055826 | Pride
Human Neuron Transdifferentiation 
ProteomicsMapping the mammalian ribosome quality control complex interactome using proximity labeling approaches
Proximity-based (APEX and BioID) and standard affinity capture proteomics of the mammalian ribosome associated quality control complex
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-31 | MSV000082006 | MassIVE
ProteomicsRibosome quality control activity potentiates vaccinia virus protein synthesis during infection
Ribosomes are highly abundant cellular machines that perform the essential task of translating the genetic code into proteins. Cellular translation activity is finely tuned and proteostasis insults, such as those incurred upon viral infection, activate stress signaling pathways that result in transl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Vaccinia Virus Wr (ncbitaxon:10254) 
2021-01-05 | MSV000086660 | MassIVE
ProteomicsZNF598 substrate identification
This study uses ubiquitin proteomics to identify substrates for the ZNF598 ubiquitin ligase
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-12-08 | MSV000080390 | MassIVE
ProteomicsContext-dependent and disease-specific diversity in stress granules formed from preexisting protein interactions
Affinity-capture proteomics studies using endogenously tagged G3BP1 with APEX2 to capture the stress granule proteome at steady state and upon stress induction. This was done in 293T cells as well as induced pluripotent stem cells differentiated into neuronal progenitor cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081554 | MassIVE
ProteomicsNeuronal aging leads to disrupted RNA metabolism
Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged (i.e. >50 yea...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD055900 | Pride
Human Neuron Transdifferentiation 
ProteomicsNeuronal aging leads to disrupted RNA metabolism
Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged (i.e. >50 yea...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD055825 | Pride
Human Lc-msms Dia 
ProteomicsEDF1 coordinates cellular responses to ribosome collisions
Raw mass spectrometry data associated with the following paper: EDF1 coordinates cellular responses to ribosome collisions. Related to Figure 2-figure supplement 2A and Figure 2-source data 2. Files detail: See attached Search Engine File named "Sample info and Maxquant summary"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-15 | MSV000085422 | MassIVE
ProteomicsEDF1 coordinates cellular responses to ribosome collisions
Raw mass spectrometry data associated with the following paper: EDF1 coordinates cellular responses to ribosome collisions. Related to Figure 5B, Figure 5-figure supplement 1B-1C and Figure 5-source data 2. Files detail: See attached Search Engine file named "Sample info and Maxquant summary"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-15 | MSV000085421 | MassIVE
ProteomicsEDF1 coordinates cellular responses to ribosome collisions
Raw mass spectrometry data associated with the following paper: EDF1 coordinates cellular responses to ribosome collisions. Related to Figure 2, Figure 2-figure supplement 1 and Figure 2-source data 1. Files detail: Monosome (6 BPRP fractions - labeled AO3104-3109); Polysome (6 BPRP fractions - labe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-15 | MSV000085419 | MassIVE
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