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ProteomicsMetabolic Reprogramming Driven by Ant2 Deficiency Augments T Cell Function and Anti-Tumor Immunity
cell activation demands a significant boost in NAD+ levels, often outpacing the capacity of oxidative phosphorylation (OXPHOS). To explore how T cells manage this metabolic stress, we created T cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mice. Ant2, which is vital for ADP/ATP exchange bet...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-09 | PXD062646 | Pride
Naive t cells Mouse Ant2ko Spleen 
TranscriptomicsTranscription profiling of human non anaplastic T-cell lymphoma
A ﾑCartes dﾒIdentite des Tumeursﾒ (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 17 AITL biopsies, 2 AITL sorted cells, 16 PTCL NOS biopsies | The molecular alterations underlying the pathogenesis of angioimmunoblast...
ORGANISM(S): Homo sapiens 
2009-09-22 | E-TABM-783 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of humuan peripheral blood mononuclear cells stimulated with interleukin-12 and unstimulated controls
The cytokine interleukin-12 (IL-12) is known to play a central role in adaptive and innate immunity. We employed microarray analysis of IL-12 induced gene expression to provide further insights into its effects on immune response. Experiment Overall Design: PBMC's were isolated from 7 healthy NIH bl...
ORGANISM(S): Homo sapiens 
2008-11-21 | E-GEOD-12839 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of biopsy samples from peripheral T-cell lymphoma (PTCL)
Molecular signatures to improve diagnosis in PTCL and prognostication in angioimmunoblastic T-cell lymphoma (AITL). Gene expression profiling of PTCL patient samples was performed to investigate whether molecular signatures can be used to identify distinct entities of PTCL. Gene expression profiling...
ORGANISM(S): Homo sapiens 
2010-02-27 | E-GEOD-19069 | biostudies-arrayexpress
ProteomicsGultamine tracing wt vs.ant2ko CD8 T cells
Glutamine tracing analysis performed on naive CD8 T cells from mouse splenocytes. Comparison between cells from wild-type and Ant2-/- mice.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-04-10 | MSV000097585 | MassIVE
TranscriptomicsTranscriptome analysis of Th9 CD4+ T cells differentiated with or without Il-1beta
We report that the Th9 differenciation program is boosted in presence of Il-1beta Examination of the expression profile of Th9 CD4+ T cells after 1 hour and 3 days of differentiation and after in vivo injection
ORGANISM(S): Mus musculus 
2014-05-23 | E-GEOD-54697 | biostudies-arrayexpress
ProteomicsShort-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
The peri-bronchial zone of chronic obstructive pulmonary disease (COPD) is the site of extensive infiltration of immune cell, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T cells and its consequences were investigated. We show that fib...
ORGANISM(S): Homo sapiens (Human) 
2023-07-28 | PXD041402 | Pride
Chemotaxis Intercellular interactions Inflammation Remodeling Chronic respiratory diseases 
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD035699 | Pride
Cutaneous t-cell lymphoma Kinases 
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035626 | Pride
Global proteomics Kinase Cutaneous t-cell lymphomas (l-ctcl) 
MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
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