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MetabolomicsEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...
2021-03-29 | MTBLS2205 | MetaboLights
ProteomicsGene expression changes in liver upon LCMV Cl13 infection.
2-3 month old female C57Bl/6J mice were intravenously infected with 2x10^6 focus forming units of lymphocytic choriomeningitis virus strain Clone-13. Whole liver tissue was harvested in duplicated from uninfected control mice, uninfected 123d old mice, and from infected at 2, 8, 30, 60, and 123 day...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-02 | PXD011122 | Pride
Lcmv Virus Liver Infection 
TranscriptomicsTranscription profiling by array of influenza PR8 infected mouse lung tissue
C57BL/6J (WT) mice were infected with influenza A virus PR/8/34 or mock infected with phosphate buffered saline (PBS). 18 hours later lung tissue was harvested for transcriptional profiling.
ORGANISM(S): Mus musculus 
2014-11-23 | E-MTAB-2845 | biostudies-arrayexpress
ProteomicsThe ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the culprit molecular underpinnings, we designed an approach that combines sensitivity to drugs with an integrated systems-biology characterization. Sensitivity to ...
ORGANISM(S): Sarcophilus harrisii 
2019-01-18 | PXD009283 | Pride
Tasmanian devil Dftd Transmissible cancer Erbb 
TranscriptomicsLCMV infection of Sod1-/- vs. WT mice
Study of host-virus interaction in the liver of Superoxide dismutase 1 (Sod1) deficient mice vs. wildtype mice.
ORGANISM(S): Mus musculus 
2015-11-17 | E-MTAB-2351 | biostudies-arrayexpress
TranscriptomicsPolyI:C stimulation of KO vs. WT BMDMs
Primary murine bone marrow derived macrophages (BMDMs) of Setdb2GT/GT and WT mice were stimulated with polyI:C and harvested at 0, 2 and 8h. Everything with biological triplicates (=cells from 3 individual mice per condition)
ORGANISM(S): Mus musculus 
2014-11-23 | E-MTAB-2263 | biostudies-arrayexpress
GenomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding...
EGAS00001005060 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
Genomics5a9f4bd6-d795-47e9-9690-979bf5b1df6b - samples
The data contains single-cell gene sequencing data (10x Genomics) from FACS-purified CD8 T lymphocytes from two Austrian patients. The cells were stimulated with one MHC class I peptides obtained from a common (wild type) variant and an emerging mutant variant of the SARS-Cov-2 virus. Then the samp...
EGAD00001006995 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
Genomics5c638551-978c-4e80-b87e-d669d6b7069e - samples
Full information about the T cell receptor (CR) variable regions found in the sequences of the vdj region. Columns: barcode is_cell contig_id high_confidence length chain v_gene d_gene j_gene c_gene full_length productive cdr3 cdr3_nt reads umis raw_clonotype_id raw_consensus_id
EGAD00001008109 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
UnknownTyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancers
Not available
S-SCDT-10_1038-S44318-025-00603-0 | biostudies-other
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