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UnknownHigher levels of host-cell DNA methylation markers ZNF582 and ASCL1 on anal smears are predictive for progression to anal cancer in patients with previous high-grade lesions.
Not available
S-EPMC12508813 | biostudies-literature
TranscriptomicsRNAi knock-down of MKL1 in human megakaryocytes derived from cord blood or cytapheresis
Characterize the genes regulated by MKL1/SRF complex in human megakaryocytes (MKs) derived from cord blood or cytapheresis : Using a knock down approach by small interference of MKL1 in MK progenitors, we observed a decrease in the percentage of cells with actin polymerization after adhesion on vari...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-TABM-640 | biostudies-arrayexpress
TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
TranscriptomicsAbnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice
Laminins are major constituents of basement membranes and are essential for tissue homeostasis. Laminin-511 is highly expressed in the intestine and its absence causes severe malformation of the intestine and embryonic lethality. To understand the mechanistic role of laminin-511 in tissue homeostasi...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-31334 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 5T33MM cells treated in vivo with quisinostat, decitabine or the combination.
Epigenetic modulating agents are under intense investigation for cancer therapy including multiple myeloma. In this study, we investigated the in vivo transcriptional response to epigenetic modulating agents in multiple myeloma using the 5T33MM model with the aim to identify potential clinical rele...
ORGANISM(S): Mus musculus 
2018-02-26 | E-MTAB-3178 | biostudies-arrayexpress
ProteomicsRole of BTG1 inactivation in lymphomagenesis and lymphoma dissemination
BTG1 is recurrently mutated in the MCD/C5 subgroup of diffuse large B cell lymphoma (DLBCL), but the functions of this gene in lymphomagenesis have never been investigated so far. Here we provide evidence that Btg1 knock out accelerates the development of a lethal lymphoproliferative disease driven ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-10 | MSV000089045 | MassIVE
UnknownPopulation pharmacokinetics of lopinavir/ritonavir in Covid-19 patients.
Not available
S-EPMC7552959 | biostudies-literature
TranscriptomicsIGR_MERCHER_LAM7
Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease generally associated with poor prognosis. Gene expression profiles indicate the existence of distinct molecular subgroups and several genetic alterations have been characterized in the past years, including the t(1;22)(p13;q13) and th...
ORGANISM(S): Homo sapiens 
2012-11-17 | E-MTAB-1370 | biostudies-arrayexpress
TranscriptomicsHematopietic system high resolution transcriptome
Recent advances in high density oligonucleotides microarray technology have generated solutions for molecular profiling of human samples at an unprecedented resolution. We mapped whole blood RNA from healthy volunteers and CD34+ collected by cytapheresis from patients to Exon ST 1.0 microarray probi...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-10480 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the Nxnl2-/- mouse retina
A nxnl2 knockout mouse model was created and the transcriptome used to demonstrate that the retina is compromised by the absence of nxnl2. For the mouse lacking Nxnl2, the gene encoding RdCVF2, the progressive decline of the visual performance of the cones in parallel with their degeneration arises ...
ORGANISM(S): Mus musculus 
2011-09-11 | E-GEOD-21863 | biostudies-arrayexpress
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