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ProteomicsCo-translational determination of quaternary structures in chaperone factories
The HSP90/R2TP quaternary chaperone assembles key cellular machines, including the three nuclear RNA polymerases and many non-coding RNPs. Here, we show that the R2TP binds many partners co-translationally. Remarkably, its co-translational interactome reveals many novel potential clients, and side-b...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD061298 | Pride
Translation factories Chaperone Co-translational assembly 
UnknownAcute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats.
Not available
S-EPMC7670727 | biostudies-literature
ProteomicsProteomics of treatment of Arabidopsis thaliana with peptides
Plants were treated with a cPEP for luciferase (PEP Luc) or a scrambled version of this peptide (4 biological replicates each). Leaves were snap frozen in liquid nitrogen and grounded into powder. The powder was resuspended in tris 50 mM and 5% SDS, sonicated and centrifuged at 14,000 g for 10 min. ...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
MSV000090305 | MassIVE
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
UnknownImpact of maintenance treatment on male gonadal function in patients treated for localized rhabdomyosarcoma in RMS2005 trial in France.
Not available
S-EPMC12117600 | biostudies-literature
TranscriptomicsBromodomain-dependent stage-specific male genome programming by Brdt [Illumina BeadArray]
Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into meiosis and characterized by major chromatin reorganizations in haploid spermatids. We report here that a single member of the double bromodomain BET factors, Brdt, is a master...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-39909 | biostudies-arrayexpress
TranscriptomicsIGR_CAP1_DOCETAXEL_GE_STUDY_AC
'Prostate cancer is the second cancer diagnosed among men worldwide. Beside approval of new therapies in the last five years, chemotherapeutic agents, docetaxel and cabazitaxel taxanes remain key treatments for metastatic castration resistant prostate cancers. However, primary and acquired resistanc...
ORGANISM(S): Homo sapiens 
2018-11-07 | E-MTAB-4869 | biostudies-arrayexpress
UnknownHighly Effective Therapies as First-Line Treatment for Pediatric-Onset Multiple Sclerosis.
Not available
S-EPMC10862269 | biostudies-literature
UnknownEmergence of psychiatric adverse events during antipsychotic treatment in AP-naive children and adolescents.
Not available
S-EPMC9655798 | biostudies-literature
UnknownProcalcitonin algorithm to guide initial antibiotic therapy in acute exacerbations of COPD admitted to the ICU: a randomized multicenter study.
Not available
S-EPMC5924665 | biostudies-literature
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