Beta secretase - OmicsDI

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Unknown (1038)
Transcriptomics (282)
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Homo sapiens (124)
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Tissue

Cerebrospinal fluid (4)
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Disease

Alzheimer's disease (3)
Not Available (2)
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Technology Type

Mass Spectrometry (12)
Bottom-up proteomics (5)
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Mass spectrometry (2)
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Instrument Platform

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- (2)
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Publication Date

2014 (39)
2015 (38)
2013 (27)
2024 (26)
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2012 (23)
2011 (23)
2010 (20)
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2005 (3)
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2004 (1)

UNIPROT ID/AC

P05067 (2)

CHEBI ID

CHEBI:37670 (1)
CHEBI:89439 (1)
CHEBI:74904 (1)
CHEBI:167610 (1)
CHEBI:31011 (1)
CHEBI:48942 (1)
CHEBI:48946 (1)
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CHEBI:17968 (1)
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CHEBI:173838 (1)
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CHEBI:15834 (1)
CHEBI:185330 (1)
CHEBI:192296 (1)
CHEBI:192169 (1)
CHEBI:165839 (1)
CHEBI:68441 (1)
CHEBI:80470 (1)
CHEBI:179516 (1)

Metabolite Name

Eicosapentaenoic acid (2)
PE(20:2(11Z,14Z)/20:4(6E,8Z,11Z,14Z)+=O(5)) (1)
PA(21:0/LTE4) (1)
CL(15:0/18:2(9Z,11Z)/18:2(9Z,11Z)/25:0) (1)
1alpha-hydroxy-23-[3-(1-hydroxy-1-methylethyl)phenyl]-22,22,23,23-tetradehydro-24,25,26,27-tetranorvitamin D3 / 1alpha-hydroxy-23-[3-(1-hydroxy-1-methylethyl)phenyl]-22,22,23,23-tetradehydro-24,25,26, 27-tetranorcholecalciferol (1)
PE(20:4(8Z,11Z,14Z,17Z)/20:4(5Z,8Z,11Z,13E)-OH(15S)) (1)
PA(21:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) (1)
PS(19:1(9Z)/20:3(8Z,11Z,14Z)) (1)
Isoscoparin 2''-(6-(E)-ferulylglucoside) (1)
CDP-DG(a-13:0/PGJ2) (1)
PE(14:0/6 keto-PGF1alpha) (1)
PS(15:0/6 keto-PGF1alpha) (1)
PS(15:0/20:4(6Z,8E,10E,14Z)-2OH(5S,12R)) (1)
PG(18:0/18:2(10E,12Z)+=O(9)) (1)
PG(18:1(11Z)/LTE4) (1)
CL(18:0/18:0/22:5(4Z,7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (1)
Mycobactin J (1)
CL(18:0/22:5(4Z,7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z)) (1)
PE(16:1(9Z)/5-iso PGF2VI) (1)
PI(16:2(9Z,12Z)/TXB2) (1)
Concanamycin a (1)
PS(16:0/PGF1alpha) (1)
DG(20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)/21:0/0:0) (1)
PA(P-16:0/LTE4) (1)
1alpha,25-dihydroxy-24a,24b-didihomo-22-thia-20-epivitamin D3 / 1alpha,25-dihydroxy-24a,24b-didihomo-22-thia-20-epicholecalciferol (1)
12,14-Heptacosadiynoic acid (1)
PC(18:1(11Z)/18:3(10,12,15)-OH(9)) (1)
PA(18:1(11Z)/LTE4) (1)
PA(12:0/20:3(8Z,11Z,14Z)-2OH(5,6)) (1)
DG(16:0/20:3(5Z,8Z,11Z)-O(14R,15S)/0:0) (1)

First Public Date

2014 (6)
2024 (5)
2019 (3)
2026 (2)
2025 (2)
2023 (2)
2022 (2)
2021 (2)
2020 (2)
2015 (2)

Modelling Approach

Ordinary differential equation model (2)
Machine learning (1)

Lab affiliation

DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (3)
DZNE Munich / TU Munich (2)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (2)
Cancer proteomics lab Department of Molecular Cell Biology Weizmann Institute of science, Rehovot, Israel (1)
DZNE Munich Neuroproteomics Feodor-Lynen-Str. 17 81377 München Germany (1)
Systematische Proteomics & Bioanalytik - Institut für Experimentelle Medizin Christian-Albrechts-Universität zu Kiel (1)
Turku Bioscience Center, University of Turku and Åbo Akademi University, 20520 Turku, Finland. Medicity Research Laboratories, University of Turku, 20520 Turku, Finland Institute of Biomedicine, University of Turku, 2520 Turku, Finland (1)
UMB, Poland (1)

IsPrivate

False (3)

Submitter Keywords

Ersilia (1)
FAIR-AIML (1)
Machine Learning Model (1)

Study type

Transcription profiling by array (172)
RNA-seq of coding RNA (37)
RNA-seq of coding RNA from single cells (9)
RNA-seq of non coding RNA (9)
Other (7)
ChIP-seq (7)
MicroRNA profiling by high throughput sequencing (5)
Methylation profiling by array (4)
Spatial transcriptomics by high-throughput sequencing (3)
Animal - High-throughput sequencing (2)
RNA-seq of total RNA (2)
Cell line - Single-cell sequencing (1)
Unknown experiment type (1)
Animal - One-color microarray (1)
Plant - High-throughput sequencing (1)
High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
Capture-C (1)
CLIP-seq (1)
Comparative genomic hybridization by array (1)
RIP-seq (1)
Single nucleus RNA sequencing (1)
MicroRNA profiling by array (1)

Release Date

2020 (112)
2022 (97)
2021 (90)
2014 (90)
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2015 (76)
2016 (74)
2019 (70)
2024 (64)
2012 (64)
2018 (61)
2017 (60)
2013 (60)
2025 (57)
2010 (53)
2011 (50)
2009 (40)
2008 (27)
2007 (22)
2026 (12)
2006 (10)
2005 (10)
2004 (9)
2002 (6)
2003 (3)
2000 (2)
1999 (2)

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Human CSF peptidomics of gamma secretase inhibition

Fifteen human healthy volunteers, divided into three groups, received a single dose of placebo or either 140 mg or 280 mg of the ?-secretase inhibitor semagacestat (LY450139). Endogenous peptides in CSF, sampled prior to administration of the drug and at six subsequent time points, were analyzed by ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-04-01 | MSV000080870 | MassIVE

CHO cells with enhanced and abolished gamma-secretase activity

Î³-secretase is an intra-membrane-cleaving aspartyl protease implicated in the processing of a wide range of type I membrane proteins including the Notch receptor and the amyloid-Î² precursor protein (APP). It thus regulates a diverse array of cellular and biological processes including the differen...

ORGANISM(S): Cricetulus griseus

2010-05-15 | E-GEOD-16379 | biostudies-arrayexpress

Das2010 - Effect of a gamma-secretase inhibitor on Amyloid-beta dynamics

Das2010 - Effect of a gamma-secretase inhibitor on Amyloid-beta dynamics This model is described in the article: Modeling effect of a ?-secretase inhibitor on amyloid-? dynamics reveals significant role of an amyloid clearance mechanism. Das R, Nachbar RB, Edelstein-Keshet L...

2024-09-02 | BIOMD0000000551 | BioModels

Ortega2013 - Interplay between secretases determines biphasic amyloid-beta level

Ortega2013 - Interplay between secretases determines biphasic amyloid-beta level This model is described in the article: Interplay between ?-, ?-, and ?-secretases determines biphasic amyloid-? protein level in the presence of a ?-secretase inhibitor. Ortega F, Stott J, Visser...

2024-09-02 | BIOMD0000000556 | BioModels

The gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells

Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...

ORGANISM(S): Homo sapiens

2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress

Transcription profiling of human T-ALL samples to investigate synergistic interaction of gamma-secretase inhibitor therapy and glucocorticoids

Glucocorticoids are an essential component of the treatment of lymphoid malignancies and resistance to glucocorticoid therapy constitutes a prominent clinical problem in relapsed and refractory lymphoblastic leukemias. Constitutively active NOTCH signaling is involved in the pathogenesis of over 50%...

ORGANISM(S): Homo sapiens

2009-01-13 | E-GEOD-7067 | biostudies-arrayexpress

Alteration in global transcriptome after Notch inhibition with gamma-secretase inhibitor MRK003 in Glioblastoma Cells

We used DNA microarrays to compare RNA transcript expression from various glioma neurospheres after treatment with gamma-secretase inhibitor MRK003. Four glioma cell lines grown as neurospheres (GBM1, GBM2, GBM10 and GBM14) were treated two concentrations of with gamma-secretase inhibitor MRK003 (Hi...

ORGANISM(S): Homo sapiens

2015-08-07 | E-GEOD-71769 | biostudies-arrayexpress

Proteolytic processing of CD99

The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-03-29 | MSV000080746 | MassIVE

Gamma secretase complex and DOCK2 affinity interactome

γ-Secretase is a transmembrane protease complex responsible for processing multiple type I transmembrane proteins, including the amyloid precursor protein (APP) and NOTCH. Using a proteomics-based screening approach, we found that dedicator of cytokinesis protein 2 (DOCK2) interacts with the γ-secre...

ORGANISM(S): Homo Sapiens

2025-06-26 | PXD065491 |

Genes regulated by the gamma secretase inhibitor in WT and Ikaros deficient DN3 cells

Lineage-negative thymocytes were cultured on OP9-DL1 stromal cells for 16h in the presence of DMSO or the gamma secretase inhibitor MRK-003. DN3 cells cells were then sorted and their transcriptome analyzed. 8 samples

ORGANISM(S): Mus musculus

2013-04-17 | E-GEOD-46091 | biostudies-arrayexpress

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