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MetabolomicsIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers imp...
2020-04-17 | MTBLS951 | MetaboLights
MetabolomicsGlycerate Production from Intestinal Fructose Metabolism Elevated by Dietary Fat Induces Glucose Intolerance Through β-cell Damage
Not available
ORGANISM(S): Mus musculus 
ST002161 | MetabolomicsWorkbench
GenomicsHuman Pancreatic Beta Cell lncRNAs Control Cell-Specific Regulatory Networks
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cel...
EGAS00001002865 | EGA
ProteomicsDevelopment of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies
β-hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemia (BT), are the most common inherited monogenic blood disorders globally. Despite decades of research, there are only four FDA-approved medications available for the management of SCD with hydroxyurea (HU) being the most widel...
ORGANISM(S): Homo sapiens (Human) 
2024-02-07 | PXD044642 | Pride
Proteomics Mass spectrometer Sickle cell disease Erythroid progenitor line Crispr/cas9 10-plex tmt label Β-thalassemia 
TranscriptomicsBeta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling
To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with beta-catenin siRNA and identified beta-catenin target genes using DNA microarrays. The list of identified target genes ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-44097 | biostudies-arrayexpress
ProteomicsPhosphoproteome of mouse pancreatic beta cell
TMT-labeled phosphoproteome data of mouse pancreatic beta cell
ORGANISM(S): Mus Musculus (mouse) 
2021-05-11 | PXD022745 | JPOST Repository
GenomicsCell-type, allelic and genetic signatures in the human pancreatic beta cell transcriptome
Pancreatic beta cells within the islets of Langerhans are centrally involved in the pathogenesis of both type 1 and type 2 diabetes. Describing the differentiated state of the human beta cell has been hampered so far by technical (low resolution microarrays) and biological limitations (whole islet p...
EGAS00001000442 | EGA
ProteomicsPancreatic beta cell proteome with increased proliferation in NOD mice
We investigated the pancreatic beta cell proteome changes in NOD-LIRKO vesus NOD where beta cell mass was enhanced early in life. Proteomics data is derived from FACS-sorted beta cells at 8 weeks and 12 weeks.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-14 | MSV000083576 | MassIVE
ProteomicsSNAPIN regulates β cell cycle progression to promote pancreatic β cell growth
SNAPIN for β cell growth is poorly understood, and our findings reveal that SNAPIN overexpression in Min6 cells can promote cell proliferation and are promising in achieving the goals of regenerative medicine for diabetes treatment.we want to find snapin interact proteins to illustrate snapin functi...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-03 | PXD023786 | Pride
Β cell Mouse Snapin 
TranscriptomicsDetailed transcriptome atlas of the pancreatic beta cell
The aim of the present study was to explore the transcriptome of pancreatic islets and, based on this information, to prepare a comprehensive and open access inventory of insulin-producing ?-cell gene expression, the beta-Cell Gene Atlas (BCGA). INS-1 cells, primary rat beta-cells (>87% beta-cells) ...
ORGANISM(S): Rattus norvegicus 
2008-12-31 | E-GEOD-13381 | biostudies-arrayexpress
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