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UnknownTHRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog.
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S-EPMC10250548 | biostudies-literature
ProteomicsLiver-metastases restrict IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer
To see how the secretome changes upon challenging organoids with immune pressure, we wanted to perform secretomics on CRC MSI organoids +- stimulation with IFNy. Secretomics was performed using a previously published metabolic labeling method based on threonine-derived non-canonical amino acid taggi...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD071538 | Pride
ProteomicsAlterations in the nascent proteome during translation attenuation in response to mitochondrial stress induced by carbonyl cyanide m-chlorophenyl hydrazine (CCCP) and in response to EEF1A1 knockdown
This submission is a part of a proteomic resource consisting of four independent datasets and their meta-analysis which describe: the detailed landscape of changes in the nascent proteome at high temporal resolution with 30 min intervals upon rapid and reversible global translation attenuation in re...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD054502 | Pride
Mitochondria Eef1a1 elongation factor Mitochondrial stress Nascent proteome Cccp 
MetabolomicsPlasma Metabolome Analysis for Predicting Antiviral Treatment Efficacy in Chronic Hepatitis B: Diagnostic Biomarkers and Therapeutic Insights
The early and accurate identification of predictive biomarkers for antiviral treatment efficacy remains a significant clinical challenge, particularly in the management of chronic hepatitis B (CHB). This study aimed to assess whether the plasma metabolome could reliably predict the success of antivi...
2024-07-10 | MTBLS10401 | MetaboLights
MetabolomicsMetabolomic Analysis of Candida albicans under Metal-based anti-fungal strategy

Based on a unique pathogen iron interplay mechanism, this work establishes a new therapeutic paradigm targeting iron homeostasis at the host-pathogen interface via sequential metabolic priming, offering a broadly applicable strategy to reprogram resource asymmetry and combat fungal infection.

2026-05-10 | MTBLS13715 | MetaboLights
MetabolomicsMetabolomic profiling of mouse colorectal tumor tissues and fecal samples following bacterial intervention
This study investigated metabolic alterations in an AOM/DSS-induced mouse colorectal tumor model following bacterial intervention with Faecalibacterium prausnitzii and Peptostreptococcus stomatis. Targeted bile acid profiling and untargeted metabolomics were performed using LC-MS on colorectal tumor...
2026-09-24 | MTBLS15620 | MetaboLights
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