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ProteomicsEndosulfines Igo1 and Igo2 promote hyperosmotic stress signaling via inhibition of protein phosphatase 2A
The hyperosmotic stress response in budding yeast is a paradigm for cellular responses to physicochemical stimuli that is often used for modeling signal transduction pathways. Here, we describe the phosphatase PP2A-Cdc55 as a novel master regulator of hyperosmotic stress signaling. We show that its ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-11-02 | PXD019646 | Pride
Stress response Phosphorylation Igo2 Gis1 Igo1 Phosphatase Pp2a Saccharomyces cerevisiae Quantitative proteomics Rph1 Hyperosmotic stress Stress signaling Cdc55 Endosulfines 
TranscriptomicsEpigenomic landscapes of human inflammation associated macrophages [RNA-seq]
We previously demonstrated by genomic and bioinformatical approaches that human macrophage (MΦ) activation is best described by a spectrum model (Xue et al, Immunity, 2014). MΦ integrate exogenous input signals on transcriptional level in a unique fashion to generate specific functional programs, ...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-66593 | biostudies-arrayexpress
GenomicsEpigenomic landscapes of human inflammation associated macrophages [ChIP-seq]
We previously demonstrated by genomic and bioinformatical approaches that human macrophage (MΦ) activation is best described by a spectrum model (Xue et al, Immunity, 2014). MΦ integrate exogenous input signals on transcriptional level in a unique fashion to generate specific functional programs, ...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-66594 | biostudies-arrayexpress
TranscriptomicsExpression data from cerebral tumors of WHO grade II and III
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor s...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-GEOD-61374 | biostudies-arrayexpress
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