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GenomicsTranscriptome profiles of BEZ235 treated Ewing Sarcoma cells
Transcriptome profiles of BEZ235 treated Ewing Sarcoma cells
PRJNA884644 | ENA
ProteomicsTargeting metabolic reprogramming by influenza infection for therapeutic intervention
Influenza infection is a worldwide health and financial burden posing a significant risk to the immune-compromised, obese, diabetic, elderly, and pediatric populations. We identified increases in glucose metabolism in the lungs of pediatric patients infected with respiratory pathogens. Using quantit...
ORGANISM(S): Homo sapiens (Human) 
2017-05-24 | PXD006263 | Pride
Metabolism Bez235 Proteomics Influenza Respiratory viral infection Pet scan 
TranscriptomicsMYC drives resistance to PI3K/mTOR targeted inhibition (gene expression)
Gene expression signatures were measured after treatment of cells with 50nM BEZ235. Affymetrix HG-U133AV2 expression arrays were performed according to the manufacturer's directions using RNA extracted by Qiagen RNeasy from engineered human cell-lines grown for 72h in the presence of 50nM BEZ235 Res...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-25172 | biostudies-arrayexpress
TranscriptomicsmTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Comparative st...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37129 | biostudies-arrayexpress
GenomicsRNA seq NVP-BEZ235 treatment of U87MG cells
RNA seq NVP-BEZ235 treatment of U87MG cells
PRJNA744516 | ENA
TranscriptomicsInfluence of BEZ235 and MYC on gene expression in SW620 cells
SW620 were transfected with siMYC or siCTR at time point 0h. 24h later cells were splitter 1:2, additional 24 h later (48h after transfection) cells were treated with BEZ235 (200nM) or DMSO. Cells were harvested after additional 24h (72h after siRNA transfection; 24h BEZ235 treatment.
ORGANISM(S): Homo sapiens 
2015-08-27 | E-MTAB-2882 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of BEZ235 treated Ewing Sarcoma cells
Transcriptome profiles of BEZ235 treated Ewing Sarcoma cells
ORGANISM(S): Homo sapiens 
2025-09-27 | GSE214256 | GEO
TranscriptomicsGene expression and alternative splicing profiles of BEZ235 treated Ewing Sarcoma cells
TC71 cells treated either with BEZ235 or DMSO
ORGANISM(S): Homo sapiens 
2018-02-14 | GSE93579 | GEO
UnknownUtility of a PI3K/mTOR inhibitor (NVP-BEZ235) for thyroid cancer therapy.
Not available
S-EPMC3471922 | biostudies-literature
UnknownActivity of BKM120 and BEZ235 against Lymphoma Cells.
Not available
S-EPMC4628710 | biostudies-literature
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