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ProteomicsDiscovery of a monoacylglycerol lipase inhibitor that harnesses the therapeutic potential of endocannabinoid signaling without CNS-mediated adverse side effects or physical dependence.
Chemical proteomics of LEI-515 in mouse lung, liver and brain tissue to assess the selectivity of the inhibitor.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD042220 | Pride
Brain Lung Liver Mouse Chemical proteomics 
ProteomicsIntegrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcript...
ORGANISM(S): Brucella Suis Bv. 1 Str. S2 
2020-11-13 | PXD022537 |
UnknownInfluence of interaction between organic cation and inorganic unit in bi-based hybrid perovskites for photoelectronic properties.
Not available
S-EPMC9803823 | biostudies-literature
ProteomicsProfiling of retinaldehyde dehydrogenases in cancer cells
Retinaldehyde dehydrogenases convert retinal into all-trans retinoic acid (ATRA), thereby regulating cell differentiation and cancer stem cell proliferation. Chemical tools and methods are valuable commodities to study aldehyde dehydrogenase (ALDH) activity in human cells. Here, we describe the desi...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD015495 | Pride
Human Cancer Activity-based protein profiling Aldehyde dehydrogenases 
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
UnknownA monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Not available
S-EPMC10698032 | biostudies-literature
TranscriptomicsExpression data from NKYS transfected with siRNAs or plasmids
The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3 siRNA to test whether it affected epigenetic regulation, and used EZH2 mutants to study how it affected EZH2 canonical function. Whole genome microa...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-75680 | biostudies-arrayexpress
UnknownIsolation and characterization of bis(silylene)-stabilized antimony(I) and bismuth(I) cations.
Not available
S-EPMC10206093 | biostudies-literature
UnknownEmpagliflozin is associated with lower risk of cardiovascular events and all-cause mortality in routine care in East Asia: Results from the EMPRISE study.
Not available
S-EPMC9951576 | biostudies-literature
TranscriptomicsmiRNA expression profiling of Human Myeloma Cell Lines Pre- and Post- 5'azacytidine Treatment
We performed genome-wide miRNA expression profiling (MEP) of a panel of four human Myeloma cell lines treated with 5'azacytidine compared to control (DMSO treatment), with the objective of unmasking miRNAs silenced by DNA hypermethylation. Total RNA, including miRNA, were extracted using Qiagen miRN...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-53850 | biostudies-arrayexpress
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