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UnknownEvaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies.
Not available
S-EPMC6226115 | biostudies-literature
UnknownBi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function.
Not available
S-EPMC6035289 | biostudies-literature
UnknownContribution of the yeast bi-chaperone system in the restoration of the RNA helicase Ded1 and translational activity under severe ethanol stress.
Not available
S-EPMC10746526 | biostudies-literature
UnknownViral PIC-pocketing: RSV sequestration of translational preinitiation complexes into bi-phasic biomolecular condensates.
Not available
S-EPMC10949503 | biostudies-literature
UnknownConcurrent stimulation and sensing in bi-directional brain interfaces: a multi-site translational experience.
Not available
S-EPMC9095704 | biostudies-literature
TranscriptomicsRNA-seq of ATDC5 cell-line with scrambled or Sox9 knockdown at 2 hours and 7 days in chondrocgenic differentiation.
Introduction: In addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early and a late (extracellular matrix associated) ph...
ORGANISM(S): Mus musculus 
2021-06-01 | E-MTAB-10333 | biostudies-arrayexpress
UnknownBi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome.
Not available
S-EPMC10806450 | biostudies-literature
TranscriptomicsTranscriptomic profiling of bone marrow cells from CML mouse models and newly diagnosed patients treated with SOS1 inhibitor BI-3406 and/or imatinib
Despite the success of BCR-ABL1 tyrosine kinase inhibitors (TKIs) like imatinib in treating chronic myeloid leukemia (CML), therapeutic resistance and disease persistence remain significant challenges. This study investigated the potential of BI-3406, a selective SOS1 inhibitor (a key activator of R...
ORGANISM(S): Mus musculus Homo sapiens 
2026-06-22 | GSE303378 | GEO
TranscriptomicsSelective Inhibitors of mTORC1 Activate 4EBP1 and Suppress Tumor Growth
The clinical benefit of current mTOR inhibitors is limited, perhaps reflecting their intrinsic pharmacological profiles. Rapamycin analogs selectively inhibit mTORC1, but fail to suppress phosphorylation of the mTORC1 substrate 4EBP1, a translational repressor that is a key driver of oncogenic mTORC...
ORGANISM(S): Homo sapiens 
2021-04-05 | GSE138417 | GEO
ProteomicsNeuronal Nsun2 deficiency is associated with codon-specific epitranscriptomic dysregulation of Gly-tRNAs and corresponding proteomic shift impacting synaptic signaling and behavior
The role of transfer (t)RNA cytosine methyl-transferases as epitranscriptomic regulators of brain proteomes remains unexplored. We report that fear memory and antidepressant-like behaviors are highly sensitive to bi-directional changes in Nsun2 tRNA methyltransferase activity in prefrontal cortex (P...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-02 | PXD023437 | Pride
Nsun2 Tmt Neurons 
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