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MetabolomicsAntimicrobial Efficacy of Bifidobacterium longum FB1-4 Cell-Free Supernatant Against MRSA: Insights into Mechanisms and Food Matrix Application

The food safety landscape faces a significant challenge from methicillin-resistant Staphylococcus aureus (MRSA), a virulent and antibiotic-resistant foodborne pathogen. This study investigates the antimicrobial properties and mechanisms of cell-free supernatant (CFS) from Bifidobacterium longum F...

2026-02-26 | MTBLS13481 | MetaboLights
MetabolomicsInsulin Resistance-Associated Bifidobacterium longum Ameliorates Prediabetes via the 6-ketoLCA/TGR5/GLP-1 axis

Background Prediabetes, a global health concern characterized by insulin resistance (IR) and closely linked to obesity, was investigated in this study to identify key gut microbiota characteristics. The development of insulin resistance is associated with gut microbiota. Therefore, identifying ke...

2026-01-14 | MTBLS13684 | MetaboLights
MetabolomicsFrom Microbiota to Metabolomics: How Bifidobacterium infantis YLGB-1496 Shields Neonates from Necrotizing enterocolitis

Bifidobacterium species are recognized as essential primary colonizers of the infant gastrointestinal tract and constitute a critical component of infant formula. Nevertheless, the precise mechanisms by which Bifidobacterium confers its protective effects against gut inflammation remain insuffici...

2025-10-20 | MTBLS13018 | MetaboLights
MetabolomicsLacto-N-tetraose mediates indole-3-lactic acid production by Bifidobacterium longum subsp. infantis to alleviate enterotoxigenic Escherichia coli-induced diarrhea in infants

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of infectious diarrhea and poses a threat to infant health. Current treatments for ETEC infection primarily rely on antibiotics，which face limitations due to resistance and side effect. In this cross-sectional study, we analyzed fecal met...

2025-08-24 | MTBLS12886 | MetaboLights
GenomicsBifidobacterium longum subsp. longum
Bifidobacterium longum subsp. longum Genome sequencing
PRJNA936654 | ENA
MetabolomicsBifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis
Alcohol-associated liver disease (ALD) has limited therapeutic options due to its complex pathogenesis. This study demonstrates the ALD-protective effects of extracellular nanoparticles derived from Bifidobacterium bifidum (BNPs), focusing on the novel concept of gut microbiota-derived nanoparticles...
2025-06-19 | MTBLS12612 | MetaboLights
TranscriptomicsRNA sequencing of Bifidobacterium longum subsp. infantis in response to various substrates
The purpose of this project was to determine the whole transcriptome response of Bifidobacterium longum subsp. Infantis to pooled and individual human milk oligosaccharides (HMO) relative to lactose Bacterial isolates grown on lactose, pooled human milk oligosaccharides (HMO), lacto-N-tetraose (LNT)...
ORGANISM(S): Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 
2015-10-28 | E-GEOD-58773 | biostudies-arrayexpress
TranscriptomicsBifidobacterium longum mutants and resistance to Heat-Shock
Transcriptional profiling of Bifidobacterium longum mutants versus wt strain in exponentional phase, with or without heat-shock treatment, and in stationary phase Keywords: Characterization of natural mutants Two B. longum mutants (NCC2912 and NCC2913) were analysed versus the wt strain NCC2705 in ...
ORGANISM(S): Bifidobacterium longum 
2010-05-17 | E-GEOD-14628 | biostudies-arrayexpress
GenomicsBifidobacterium longum
Bifidobacterium longum Raw sequence reads
PRJNA680454 | ENA
ProteomicsSuccession of Bifidobacterium longum strains in response to a changing early life nutritional environment reveals dietary substrate adaptations
Diet-microbe interactions play a crucial role in infant development and modulation of the early-life microbiota. The genus Bifidobacterium dominates the breast-fed infant gut, with strains of B. longum subsp. longum (B. longum) and B. longum subsp. infantis (B. infantis) particularly prevalent withi...
ORGANISM(S): Bifidobacterium longum subsp. longum 
2020-07-15 | PXD017277 | Pride
Cellobiose Bifidobacterium 2'fucosyllactose Lactoneotetraose 
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