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TranscriptomicsAnalysis of miRNA profiles in CD4+ T-lymphocytes following exposure to HIV-1
Assessment of the extent to which the altered profiles of miRNA expression influence viral replication and latency, as well as the efficiency of host defenses, may be useful for understanding the basis of the HIV-1-related alterations in cellular physiology and immunologic control. To this end, thre...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-33514 | biostudies-arrayexpress
GenomicsMethyl-CpG-binding domain (MBD) sequencing of 15 primary stage 4S neuroblastoma tumors
The DNA methylome of 15 primary stage 4S neuroblastoma tumors is profiled by enrichment with a methyl-CpG-binding domain (MBD) and massively parallel sequencing DNA of 15 primary stage 4S tumors is sheared (fragments of ± 200 bp), followed by MBD-based (MethylCap kit of Diagenode) enrichement, libr...
ORGANISM(S): Homo sapiens 
2015-12-15 | E-GEOD-69268 | biostudies-arrayexpress
TranscriptomicsIdentification of genes upregulated by MeTA-array in human pancreatic cancers
Identification and characterization of epigenetically silenced genes is very important for cancer research. Particularly, information of hypermethylated genes provides clues to understand roles of epigenetics in tumorigeneses, and genes frequently methylated in a tumor-specific manner can be used as...
ORGANISM(S): Homo sapiens 
2012-12-11 | E-GEOD-26215 | biostudies-arrayexpress
UnknownDiagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases.
Not available
S-EPMC4160728 | biostudies-literature
TranscriptomicsCpG island methylation in colorectal cancer
To globally define methylation-M-bM-^@M-^YproneM-bM-^@M-^Y and -M-bM-^@M-^YprotectedM-bM-^@M-^Y CpG islands in cancer, we analyzed the methylation status of 23,000 CpG islands of the human genome in 19 colorectal carcinoma samples as well as normal colon using our previously described methyl-CpG imm...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-25221 | biostudies-arrayexpress
GenomicsIdentification of a novel set of DNA methylation markers in bladder cancer using MBD-methylCap/seq and urine DNA screening in a Chinese population
The aim of the present study was to identify novel DNA methylation markers in bladder cancer (BCa) through genome-wide profiling of bladder cancer cell lines and subsequent MSP screening in urine samples. Experimental Design: MBD methylCap/seq was carried out to screen differentially methylated CpG ...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-33839 | biostudies-arrayexpress
GenomicsThe characteristics of genome-wide DNA methylation in naM-CM-/ve CD4+ T cells of patients with psoriasis and atopic dermatitis
Psoriasis and atopic dermatitis (AD) are characterized by polarized CD4+ T cell responses. During the polarization of naM-CM-/ve CD4+ T cells, DNA methylation plays an important role in the regulation of gene transcription. In this study, we profiled the genome-wide DNA methylation status of naM-CM-...
ORGANISM(S): Homo sapiens 
2012-03-17 | E-GEOD-35582 | biostudies-arrayexpress
GenomicsQuality evaluation of Methyl Binding Domain based kits for enrichment DNA-methylation sequencing
Purpose: to compare different Methyl Binding Domain (MBD) based kits for DNA-methylation sequencing using Reduced Representation Bisulfite Sequencing (RRBS) data for validation, and to determine whether data quality can also be derived from inherent sequence data characteristics MBD-seq using 5 diff...
ORGANISM(S): Homo sapiens 
2013-01-23 | E-GEOD-42790 | biostudies-arrayexpress
GenomicsMethylation-dependent and -independent genomic targeting principles of the MBD protein family
In order to gain insight into DNA methylation readout, we have established a controlled strategy for profiling genomic targeting of chromatin-interacting factors in vivo. With this approach we determined binding preferences for the methyl-CpG binding domain (MBD) family of proteins, including diseas...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-39610 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblast cells transfected with a MDB-VP16 fusion to identify possible target genes for MBD1
We compared cells transfected with a MBD-VP16 fusion, with cells transfected with a control construct.
The purpose was to turn a repressor protein (MBD1) into an activator, and use differences in transcription to identify possible gene promoter targets.
A common reference was employed for all ...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-MTAB-103 | biostudies-arrayexpress
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