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TranscriptomicsOncostatin M effects in IMR90 cells
The JAK2 mutation V617F is detectable in a majority of patients with Ph-negative myeloproliferative neoplasms (MPN). Enforced expression of JAK2 V617F in mice induces myeloproliferation and bone marrow (BM) fibrosis suggesting a causal role for the JAK2 mutant in the pathogenesis of MPN. However, li...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-29655 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of interferon-beta stimulated cells
Cytoplasmic DNA triggers the activation of the innate immune system. While downstream signaling components have been characterized, the DNA sensing components remain largely elusive. We performed a systematic proteomics screen for proteins that associate with DNA, traversed to a screen for IFN-β-ind...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-14413 | biostudies-arrayexpress
TranscriptomicsGene expression signatures of HO-1 in BeWo cells
Heme Oxygenase-1 (HO-1) is expressed in many cancers and influences the growth, survivall and metastasis of tumors, however, the molecular mechanisms remains largely unknown. To identify a common mechanism of action of HO-1 in cancer, we studied the global effect of HO-1 on the transcriptome of mul...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-20404 | biostudies-arrayexpress
TranscriptomicsComparison of two hepatocellular cancer cell lines with distinct properties regarding epithelial-mesenchymal transition
The epithelial to mesenchymal transition (EMT) of malignant hepatocytes is a crucial event in hepatocellular carcinoma (HCC) progression and recurrence. We aimed to establish a human model of EMT to examine drug efficacy and specificity in HCC progression. Human HCC cell populations were characteriz...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-26391 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression in murine liver by IL-6
STEAP4 is a plasma membrane metallo-reductase involved in the transport of iron and copper. Recently, STEAP4 was implicated in promoting insulin sensitivity by acting in white adipose tissue (WAT) to control the production of inflammatory cytokines such as IL-6. Indeed, the loss of STEAP4 expression...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-21060 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of trophoblast cell lines
Invasive extravillous trophoblasts (EVTs) of the human placenta are critically involved in successful pregnancy outcome since they remodel the uterine spiral arteries to increase blood flow and oxygen delivery to the placenta and the developing fetus. To gain more insights into their biological role...
ORGANISM(S): Homo sapiens 
2010-09-23 | E-GEOD-20510 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in NCoR deficient mouse livers
The thyroid hormone receptor (TR) has been proposed to regulate target genes in the absence of triiodothyronine (T3), through the recruitment of the corepressors, NCoR and SMRT. NCoR and SMRT may thus play a key role in both hypothyroidism and resistance to thyroid hormone, though this has never bee...
ORGANISM(S): Mus musculus 
2008-12-03 | E-GEOD-10001 | biostudies-arrayexpress
TranscriptomicsGenes upregulated by HLX
HLX was found as a VEGF-A induced gene in HUVEC (B.Schweighofer, submitted). In order to detect genes regulated by HLX HUVEC were infected by recombinant adenovirus expressing HLX for 4, 8, 16 and 32h. RNA was isolated and subjected to microarray analysis using Affymetrix microarray. HUVEC were inf...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-13054 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and n...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-26656 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC IL-1 stimulated cells
Endothelial cells comprise a key component of the inflammatory response. HUVEC (human umbilical vein endothelial cells) were stimulated with interleukin-1 for 0, 0.5, 1, 2.5 and 6 hours, and analyzed using Affymetrix U133A microarrays, in order to obtain a comprehensive overview of the immediate ear...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-973 | biostudies-arrayexpress
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