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GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
GenomicsSmchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
X chromosome inactivation involves multiple levels of chromatin modification, established progressively and in a stepwise manner during early development. The chromosomal protein Smchd1 has recently been shown to play an important role in DNA methylation of CpG islands (CGIs), a late step in the X i...
ORGANISM(S): Mus musculus 
2012-10-15 | E-GEOD-37333 | biostudies-arrayexpress
TranscriptomicsDistinct and sexually dimorphic X dosage compensation states in the mammalian germline
This experiment depicts RNA-Seq datasets from wild type XY male and XX female, as well as sex chromosomally abnormal XO female (Turner syndrome) and XX male (Klinefelter variant syndrome) mouse germ cells before, during and after germline reprogramming. This range from E6.5 epiblasts, fluorescence a...
ORGANISM(S): Mus musculus 
2017-02-06 | E-MTAB-4616 | biostudies-arrayexpress
GenomicsAssessing SMARCA4 restoration contribution to global changes in p300 occupancy in BIN-67 cells
We aim to test how SMARCA4 restoration impacts p300 occupancy distribution. To this aim we generated ChIP-seq samples in BIN-67 with or without A-485 treatment (1 μM, 24h), as a proxy for p300 acetylatransferase inhibition, and BIN-67 with inducible SMARCA4 restoration (1 μg/ml Doxycycline for 24h)....
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15699 | biostudies-arrayexpress
UnknownKinetic Modeling for Photo-Assisted Penicillin G Degradation of (Mn0.5Zn0.5)[CdxFe2-x]O4 (x ≤ 0.05) Nanospinel Ferrites.
Not available
S-EPMC8070312 | biostudies-literature
TranscriptomicsTranscription profiling of Populus x canescens fine roots inoculated with Paxillus involutus in response to salt stress
Populus x canescens was inoculated with Paxillus involutus and grown in a climate chamber for 13 weeks. Afterwards, plants were salt stressed for 18 additional days with 150 mM NaCl in the nutrient solution. This resulted in 4 different treatments: no mycorrhiza
control (NC), mycorrhiza/control (...
ORGANISM(S): Populus tremula x Populus alba 
2009-09-16 | E-MEXP-1874 | biostudies-arrayexpress
GenomicsTo examine the role of p300 in the SMARCA4–p53 regulatory axis, we performed ChIP-seq to assess p300, p53, H3K27ac, HDAC1, HDAC2 occupancy in BIN-67 cells
ChIP-seq was performed in BIN-67, BIN-67 p53ko, BIN-67 with SMARCA4 restoration and BIN-67 p53ko cells with SMARCA4 restoration to assess the impact of SMARCA4 and p53 on the pull downs of p300, H3K27ac, p53, HDAC1 and HDAC2.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15700 | biostudies-arrayexpress
TranscriptomicsENCODE Cold Spring Harbor Labs Long RNA-seq (hg18)
This track depicts high throughput sequencing of long RNAs (>200 nt) from RNA samples from tissues or subcellular compartments from ENCODE cell lines. The overall goal of the ENCODE project is to identify and characterize all functional elements in the sequence of the human genome. For data usage te...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-32931 | biostudies-arrayexpress
TranscriptomicsENCODE Cold Spring Harbor Labs Long RNA-seq (hg19)
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Carrie Davis mailto:davisc@cshl.edu (experimental), Alex Dobin mailto:dobin@cshl.edu (computational), Felix Schlesinger mailto:schlesin@cshl.edu (computational), Tom Gingeras mailto:g...
ORGANISM(S): Homo sapiens 
2011-07-13 | E-GEOD-30567 | biostudies-arrayexpress
TranscriptomicsAnalysis of allele specific expression and its chromatin state to identify genes that are escaping X chromosome inactivation
Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the in...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-62966 | biostudies-arrayexpress
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