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ProteomicsBioactive natural product peptide discovery in fungal secretoms using PepSAVI-MS
Fungal secondary metabolites represent a rich and largely untapped source for bioactive molecules, including peptides with substantial structural diversity and pharmacological potential. As methods proceed to take a deep dive into fungal genomes, complimentary methods to identify bioactive component...
ORGANISM(S): Ustilago maydis virus P4 
2018-02-19 | PXD006931 | Pride
Peptidomics Mass spectrometry Fungal secretome analysis Bioactive peptides 
GenomicsBioactive peptides from Channa striatus
Exploration of bioactive peptides from innate immune molecules of Channa striatus
PRJEB25012 | ENA
TranscriptomicsTranscription profiling of human cell lines freely cycling treated with 164 distinct small molecules - Broad Connectivity Map CMAP Set 1
A reference collection of genome-wide transcriptional expression data for bioactive small molecules. Experiment Overall Design: The current collection (build01) contains data for 164 distinct small molecules applied to freely cycling human cell lines, represented by 453 individual treatment and matc...
ORGANISM(S): Homo sapiens 
2008-12-06 | E-GEOD-5258 | biostudies-arrayexpress
TranscriptomicsThe molecular phenotype of endocapillary proliferation in IgA nephropathy and potential modulation by bioactive small molecules
Endocapillary proliferation is associated with higher risk of progressive disease in IgAN. To better understand molecular pathways involved in the development of endocapillary proliferation and to identify novel specific therapeutic targets, we evaluated the glomerular transcriptome of microdissecte...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-50469 | biostudies-arrayexpress
ProteomicsMapping Protein Targets of Bioactive Small Molecules using Lipid-Based Chemical Proteomics
Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes combined with quantitative mass spectrometry to globally map lipid-protein interactions, and the effects of drugs on these interactions, in cells. ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-26 | PXD007570 | Pride
Hek293t Neuro2a Orbitrap velos Chemoproteomics Lipid probes 
UnknownBioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome.
Not available
S-EPMC12818350 | biostudies-literature
ProteomicsExploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1
Background. As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are necessary to replenish our dwindling arsenal of antimicrobial agents. To this end, we developed the PepSAVI-MS pipeline to expedite the...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2018-07-23 | PXD009003 | Pride
Peptidomics Antimicrobial peptides (amps) Bacterial secretome Mass spectrometry Enterococcus faecalis Bioactive peptides Natural products 
UnknownPaired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules.
Not available
S-EPMC8864700 | biostudies-literature
ProteomicsAmaranthus hypochondriacus seeds as a rich source of cysteine rich bioactive peptides
Amaranthus hypochondriacus is a highly nutritious alternative grain native to Central and South America but consumed worldwide. Increased interest in A. hypochondriacus has driven characterization of bioactive secondary metabolites and their impact on the human body. A. hypochondriacus seeds are kno...
ORGANISM(S): Amaranthus hypochondriacus 
2023-07-20 | PXD025965 | Pride
Peptidomics Proteomics Alternative grain Amaranthus hypochondriacus Mass spectrometry Cysteine rich peptides 
UnknownLight-Triggered Release of Bioactive Molecules from DNA Nanostructures.
Not available
S-EPMC4959465 | biostudies-literature
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