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TranscriptomicsGlobal gene expression profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: Similarities in the molecular landscape to human liver cancer.
Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Although the risk factors of human HCC are well known, the molecular characterization of this disease is complex, and treatment options in general remain poor. The use of rodent models to study human cancer ha...
ORGANISM(S): Mus musculus 
2011-06-06 | E-GEOD-26538 | biostudies-arrayexpress
TranscriptomicsRenal Cell Carcinomas in Vinylidene Chloride Exposed Male B63FC1 Mice Are Characterized by Oxidative Stress and TP53 Overexpression
Vinylidene Chloride has been widely used in the production of plastics and flame retardants. Exposure of B6C3F1 to VDC in the 2-year National Toxicology Program carcinogenicity bioassay resulted in a dose-dependent increase in renal cell hyperplasias, adenomas, and carcinomas (RCCs). Global gene exp...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-67320 | biostudies-arrayexpress
GenomicsAboveground bioassay for Synchytrium endobioticum
An alternative bioassay for Synchytrium endobioticum demonstrates the expression of potato wart resistance in aboveground plant parts
PRJEB30662 | ENA
TranscriptomicsIdentification and characterization of potent, broad-spectrum antifungal compounds using a yeast reporter bioassay.
New antifungal drugs are urgently needed due to the currently limited selection, the emergence of drug resistance, and the toxicity of several commonly used drugs. To identify drug leads, we screened small molecules using a Saccharomyces reporter bioassay in which the yeast heterologously expresses...
ORGANISM(S): Candida albicans 
2012-04-30 | E-GEOD-35105 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of hepatocellular carcinomas in B6C3F1 mice induced by Ginkgo biloba extract by gavage for two years
Ginkgo biloba leaf extract (GBE) has been used for centuries in traditional Chinese medicine and today is used as an herbal supplement for various indications such as improving neural function, anti-oxidant and anti-cancer effects. As part of the herbal supplement industry, these compounds are large...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-29813 | biostudies-arrayexpress
TranscriptomicsGenomic profiling reveals unique molecular alterations in hepatoblastomas and adjacent hepatocellular carcinomas in B3C3F1 mice
The cell of origin of hepatoblastoma in humans and mice (HB) is unknown; it has been hypothesized to be a transformed hepatocyte, an oval cell, or a multipotent hepatic progenitor cell. In mice, the current dogma is that HBs arise within hepatocellular neoplasms as a result of further transformation...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-67316 | biostudies-arrayexpress
TranscriptomicsTranscriptional Biomarkers to Predict Female Mouse Liver Tumors in Rodent Cancer Bioassays - A 26 Chemical Set
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2010-03-08 | E-GEOD-18858 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with carcinogens and controls to identify biomarkers
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-5128 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung treated with carcinogens and controls to evaluate carcinogenicity and identify biomarkers
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-5127 | biostudies-arrayexpress
UnknownWHO cone bioassay boards with or without holes: relevance for bioassay outcomes in long-lasting insecticidal net studies.
Not available
S-EPMC9762087 | biostudies-literature
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