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Efficacy,safety and biodistribution of intranasally delivered adenoviral COVID-19 vaccines in hamsters
Extracellular vesicles (EVs) are released by cells to mediate intercellular communication under pathological and physiological conditions. While small EVs (sEVs; <100–200 nm, exosomes) are intensely investigated, the properties and functions of medium and large EVs (big EVs [bEVs]; >200 nm, microves...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-08 | PXD037706 | Pride
A Biodistribution Study of OTV vs. ASO by Intravenous or Intrathecal Administration in Cynomolgus Monkeys
ATV-TfR and ATV-CD98hc biodistribution in the mouse brain
Coronavirus disease 2019 (COVID-19) continues to cause outbreaks around the world despite the vast COVID-19 vaccination programs. Thus, it is important to continue developing better vaccines to protect vulnerable populations. Here, we studied the efficacy, safety, persistence and biodistribution of ...
ORGANISM(S): Cricetulus griseus 
2026-08-03 | GSE301174 | GEO
The objective of this study is to evaluate ASO biodistribution and pharmacodynamic response following intravenous delivery of conjugated OTV, which utilizes transferrin-receptor binding to deliver ASO, vs. intrathecal delivery of naked ASO in cynomolgus monkeys, the current gold standard for ASO del...
ORGANISM(S): Macaca fascicularis 
2024-02-12 | GSE208114 | GEO
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