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MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
MetabolomicsThe microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the gut
Gut microbiomes play a key role in the maintenance of host metabolic homeostasis and health. An important aspect of metabolism is its circadian regulation, but how the microbiome regulates metabolite cycling under different conditions, including variations in dietary composition, remains undefined. ...
2025-04-08 | MTBLS8819 | MetaboLights
MetabolomicsThe circadian clock of Populus affects physiological, transcriptional and metabolomic responses to osmotic and ionic components of salt stress

The circadian oscillator is an innate timing mechanism present in most organisms, including plants. In this study, Populus tremula × P. tremuloides (Populus) trees with reduced expression of circadian clock components were exposed to gradually increa...

2025-10-02 | MTBLS9552 | MetaboLights
Transcriptomicstranscriptional analysis of breast circadian clock
Circadian clocks drive ~24 hr rhythms in tissue physiology. They rely on transcriptional/translational feedback loops driven by interacting networks of clock complexes.To gain insights into the role of the mammary clock, circadian time-series microarrays were performed to identify rhythmic genes in ...
ORGANISM(S): Mus musculus 
2017-12-01 | E-MTAB-5330 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Clock mutant dorsal skin at telogen
Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadia...
ORGANISM(S): Mus musculus 
2009-07-17 | E-GEOD-13579 | biostudies-arrayexpress
TranscriptomicsSKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis
Circadian clocks generate endogenous rhythms in most organisms from cyanobacteria to humans and facilitate entrainment to environmental diurnal cycles, thus conferring a fitness advantage. Both transcriptional and posttranslational mechanisms are prominent in the basic network architecture of circad...
ORGANISM(S): Arabidopsis thaliana 
2012-12-13 | E-GEOD-32216 | biostudies-arrayexpress
ProteomicsDirect evaluation of metabolic rhythms from quantitative circadian proteomics revealed rampant post-transcriptional regulation by Chlamydomonas clock
Temporal dynamics in an organism's behavior, physiology, metabolism, and biochemistry over the course of 24 hours are governed by an inherent cellular clock. Transcriptomic studies revealed that the clock is governed by intricate transcriptional and translational feedback loops(TTFLs) involving dail...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-05-27 | PXD043839 | Pride
Post-transcriptional regulations Swath-ms Proteomics C. reinhardtii Circadian clock 
TranscriptomicsCircadian skeletal muscle_wt and Clock mutants
One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into ...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-3746 | biostudies-arrayexpress
TranscriptomicsTemporal transcriptomics suggest that twin-peaking genes reset the clock
The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. To reveal the true nature of circadian variation in the mammalian SCN transcriptome we combined laser-capture microdissect...
ORGANISM(S): Mus musculus 
2015-11-03 | E-GEOD-72095 | biostudies-arrayexpress
Transcriptomicscircadian clock in cartilage
This experiment investigated the circadian clock in mice cartilage. A microarray time-series was performed using xiphoid tissue (metasternum) from mice in constant darkness. Time points were every 4 hr for 40 hr in total.
ORGANISM(S): Mus musculus 
2013-10-19 | E-MEXP-3780 | biostudies-arrayexpress
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