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MetabolomicsBiosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria
A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemica...
2017-07-18 | MTBLS454 | MetaboLights
MetabolomicsA Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato
In response to biotic stress, plants produce suites of highly modified fatty acids that bear unusual chemical functionalities. Despite their chemical complexity and proposed roles in pathogen defense, little is known about the biosynthesis of decorated fatty acids in plants. Falcarindiol is a protot...
2022-01-17 | MTBLS1039 | MetaboLights
Metabolomics,MultiomicsGNPS - Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora
Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora
ORGANISM(S): Salinispora (ncbitaxon:168694) 
2016-01-27 | MSV000079484 | GNPS
TranscriptomicsGlobal analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways
The eubacterial species Streptomyces coelicolor proceeds through a complex growth cycle in which morphological differentiation/development is associated with a transition from primary to secondary metabolism and the production of antibiotics. We used DNA microarrays and mutational analysis to invest...
ORGANISM(S): Streptomyces coelicolor 
2005-07-23 | E-GEOD-2983 | biostudies-arrayexpress
TranscriptomicsCross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor
A complex programme of regulation governs gene expression during development of the morphologically and biochemically complex eubacterial genus Streptomyces. Earlier work has suggested a model in which 'higher level' pleiotropic regulators activate 'pathway-specific' regulators located within chromo...
ORGANISM(S): Streptomyces coelicolor 
2006-02-01 | E-GEOD-4138 | biostudies-arrayexpress
GenomicsGenome mining for haemolysin biosynthetic gene clusters in Brachyspira species
Genome mining for haemolysin biosynthetic gene clusters in Brachyspira species
PRJEB94013 | ENA
MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
ModelsNassar2022 - Biosynthetic Gene Cluster (BGC) genes NER model
bgc-gene-name model is a Named Entity Recognition (NER) model that identifies and annotates the genes of Biosynthetic Gene Clusters (BGCs) in texts.
2022-03-10 | MODEL2203040005 | BioModels
Not Peer Reviewed 
ModelsNassar2022 - Biosynthetic Gene Cluster (BGC) products NER model
bgc-gene-product model is a Named Entity Recognition (NER) model that identifies and annotates the protein products of Biosynthetic Gene Clusters (BGCs) in texts.
2022-03-10 | MODEL2203040006 | BioModels
Not Peer Reviewed 
ModelsNassar2022 - Biosynthetic Gene Cluster (BGC) compound NER model
bgc-compound model is a Named Entity Recognition (NER) model that identifies and annotates the compounds of Biosynthetic Gene Clusters (BGCs) in texts.
2022-03-10 | MODEL2203040004 | BioModels
Not Peer Reviewed 
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