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ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
UnknownMultiple Myeloma in Patients over 80: A Real World Retrospective Study of First Line Conservative Approach with Bortezomib Dexamethasone Doublet Therapy and Mini-Review of Literature.
Not available
S-EPMC9564122 | biostudies-literature
UnknownMitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia.
Not available
S-EPMC10079528 | biostudies-literature
UnknownDihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein.
Not available
S-EPMC10020442 | biostudies-literature
TranscriptomicsMutations in RAS pathway induce synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia
Bulk RNAseq of primary AML samples at diagnosis
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10048 | biostudies-arrayexpress
UnknownAntileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia.
Not available
S-EPMC7581748 | biostudies-literature
UnknownVenetoclax combination therapy induces deep AML remission with eradication of leukemic stem cells and remodeling of clonal haematopoiesis.
Not available
S-EPMC7979724 | biostudies-literature
ProteomicsAntileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis. Vacuolar protein sorting 34 (VPS34) is a member of the phosphatidylinositol-3-kinase lipid kinase family that controls the canonical autophagy pathway and vesicular trafficking. Using a recently developed specific inhibitor...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD016839 | Pride
Vps34-in1 Autophagy L-asparaginase Vps34 Human molm-14 cells Orbitrap fusion Aml 
UnknownIntegrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia.
Not available
S-EPMC12712020 | biostudies-literature
UnknownTargeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition.
Not available
S-EPMC4608389 | biostudies-literature
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