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ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engage in antiapoptotic role at mitochondria following DNA damage. The different functions of ATR in the nucleus and cytoplasm are ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031385 | Pride
Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase), and PP2A regulate ATRS428P429 isomerization, they act oppositely depending on the phosphorylation status of ATR(S428). In addition, whether the isomerization at the ATR-S428P429 motif along with the BH3 domain accessibility is exclusively respons...
ORGANISM(S): Escherichia coli 
2026-09-08 | PXD054542 | Pride
Nitric oxide being a versatile molecule inside biological systems, from being both a cell signaling molecule to a potent stress agent, has significant effect in the transcriptional response in fission yeast. We have used fission yeast microarrays to identify cellular targets of Nitric Oxide (NO) and...
ORGANISM(S): Schizosaccharomyces pombe 
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