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TranscriptomicsRacial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c
Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n=70) and white (n=84) subjects. Numerous differentially expressed (DE) RNAs were associated with both race and PAR4 reactivity, including p...
ORGANISM(S): Homo sapiens 
2013-11-15 | E-GEOD-49921 | biostudies-arrayexpress
TranscriptomicsInterleukin-7 promotes monocyte/macrophage arrest on endothelial cells
Background: It is recognized that atherosclerosis can regresses at least in animal models. However, little is known about the mechanisms. We induced regression of advanced atherosclerosis in apolipoprotein E deficient (APOE­/­) mice and studied underlying mechanisms. Unexpectedly, our study led to t...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-15914 | biostudies-arrayexpress
TranscriptomicsCarbon-Deprivation-Driven Transcriptome Reprogramming in Detached Developmentally-Arresting Arabidopsis Inflorescences
Senescence is genetically-controlled and activated in mature tissues during ageing. However, immature plant tissues also display senescence-like symptoms when continuously exposed to adverse energy-depleting conditions. We used detached dark-held immature inflorescences of Arabidopsis thaliana to un...
ORGANISM(S): Arabidopsis thaliana 
2012-09-25 | E-GEOD-41099 | biostudies-arrayexpress
UnknownHome-Time, Mortality, and Readmissions Among Patients Hospitalized With Heart Failure: A Baseline Prior to IMPLEMENT-HF.
Not available
S-EPMC11479851 | biostudies-literature
TranscriptomicsRoot transcriptome remodeling of Arabidopsis in response to high levels of magnesium sulfate
Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars. However, hydrated magnesium sulfate mineral levels in the regolith of Mars can reach as high as 10 wt%, and would be expected to be highly...
ORGANISM(S): Arabidopsis thaliana 
2010-09-17 | E-GEOD-20109 | biostudies-arrayexpress
TranscriptomicsMucosal transcriptomics implicates under expression of FAM5C in the pathogenesis of ulcerative colitis
Background and aims: Mucosal abnormalities are potentially important in the primary pathogenesis of ulcerative colitis (UC). We investigated the mucosal transcriptomic expression profiles of biopsies from patients with UC and healthy controls (HC), taken from macroscopically non-inflamed tissue fr...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-48634 | biostudies-arrayexpress
TranscriptomicsIdentification of a genomic signature in BRCA1-mutated triple negative breast cancer by Comparative Genomic Hybridization
Determination of recurrent chromosomal aberrations in Luninal A, Luminal B, HER2-positve, and triple negative breast cancers 131 samples, Tumour DNA vs Normal DNA
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-54140 | biostudies-arrayexpress
TranscriptomicsCardiomyocyte-specific Nitric Oxide Synthase 3 Overexpression in Pressure-Overloaded Left Ventricle.
Aims: Cardiomyocyte-specific nitric oxide synthase 3 (NOS3) overexpression reduces left ventricular (LV) remodelling after myocardial infarction in mice, but its effect on sustained LV pressure-overload remains incompletely understood. We investigated LV structural and functional adaptation to eleva...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-37597 | biostudies-arrayexpress
TranscriptomicsDynamic tumor growth patterns in a novel murine model of colorectal cancer
Colorectal cancer often arises from adenomatous polyps. Polyps can grow and progress to cancer, but may also remain static in size, regress, or resolve. Prediciting which progress to cancer and which remain benign is difficult. We developed a long-lived murine model of colorectal cancer with tumo...
ORGANISM(S): Mus musculus 
2014-05-03 | E-GEOD-46626 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38218 | biostudies-arrayexpress
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