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TranscriptomicsHsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Atrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administer...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-66724 | biostudies-arrayexpress
TranscriptomicsTargeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects
Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disease of the hematopoietic system, which is caused by heterozygous mutations in RUNX1. FPD/AML patients have a bleeding disorder characterized by thrombocytopenia with reduced platelet numb...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-54295 | biostudies-arrayexpress
GenomicsSequencing of heritable Bleeding and Platelet Disorders
The BRIDGE-BPD study aims to discover new causal genes for Bleeding and Platelet Disorders (BPD) by high throughput sequencing using cluster analyses based on improved and standardized deep phenotyping of cases. BPD is one of the 13 Rare Disease projects under the NIHR BioResource Rare Diseases BRID...
EGAS00001001172 | EGA
GenomicsRNA-seq analysis of megakaryocytes and granulocytes in Quebec platelet disorder
Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine. The cause is tandem duplication of a 77 kb region of chromosome 10 containing PLAU and C10orf55. Blood cells and cult...
EGAS00001001840 | EGA
UnknownHow I approach bleeding in hospitalized patients.
Not available
S-EPMC10562531 | biostudies-literature
GenomicsBleeding
As part of the Bloodomics collaboration we have several categories of pedigrees with diseases/syndromes relevant to cardiovascular diseases (CVD). One such group, is from individuals who exhibit severe bleeding with an unknown cause. Exome sequencing has been performed as part of a discovery progra...
EGAS00001000106 | EGA
ProteomicsPathogenesis of dominant-negative mutant GFI1B and associated proteomic abnormalities in megakaryocytes and platelets
Dominant-negative mutations in transcription factor Growth Factor Independence-1B (GFI1B) cause a bleeding disorder characterized by a plethora of megakaryocyte and platelet abnormalities. The deregulated molecular mechanisms and pathways are unknown. Here we show that normal and mutant GFI1B inter...
ORGANISM(S): Homo sapiens (Human) 
2019-01-25 | PXD009020 | Pride
Megakaryocytes Lsd1 Bleeding disorder Lc-ms Proteomics Platelet Gfi1b 
GenomicsPomalidomide for the Treatment of Bleeding in HHT (PATH-HHT)
Pomalidomide for the Treatment of Bleeding in HHT (PATH-HHT)
PRJNA1231602 | ENA
GenomicsPomalidomide for the Treatment of Bleeding in HHT (PATH-HHT)
Pomalidomide for the Treatment of Bleeding in HHT (PATH-HHT)
PRJNA1231600 | ENA
UnknownMild or moderate hemophilia is not always a mild or moderate bleeding disorder: Back to the clinical phenotype.
Not available
S-EPMC11934897 | biostudies-literature
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