Blood brain barrier

Show results for

Unknown (9434)
Genomics (728)
Transcriptomics (676)
Proteomics (171)
Metabolomics (19)
Other (12)
Models (8)
Genomic (3)
Methylation profiling (3)
Clinical (1)
Multiomics (1)

Organisms

Mus musculus (364)
Homo sapiens (272)
Rattus norvegicus (55)
Danio rerio (16)
Drosophila melanogaster (9)
Streptococcus mutans (5)
Macaca fascicularis (5)
Enterococcus faecalis OG1RF (4)
Streptococcus suis 05ZYH33 (4)
Xenopus laevis (3)
Streptococcus mutans UA159 (2)
Squalius pyrenaicus (2)
Cronobacter sakazakii ATCC BAA-894 (2)
unidentified (2)
Cryptococcus neoformans (2)
Macaca mulatta (2)
Mus (2)
Sus scrofa (2)
Tetrahymena thermophila (1)
Streptococcus agalactiae (1)
Neisseria meningitidis (1)
Porphyromonas gingivalis (1)
Salmo salar (1)
Triticum aestivum (1)
Canis lupus familiaris (1)
Saccharomyces cerevisiae (1)
Cronobacter malonaticus (1)
Cronobacter turicensis (1)
Cronobacter muytjensii (1)
Cronobacter dublinensis (1)

Organisms

Mus musculus (283)
Homo sapiens (184)
Rattus norvegicus (36)
Danio rerio (13)
Drosophila melanogaster (8)
Xenopus laevis (2)
Macaca fascicularis (2)
rat gut metagenome (2)
Mus (2)
Streptococcus suis 05ZYH33 (2)
feces metagenome (2)
Streptococcus iniae IUSA1 (1)
Pasteurella multocida subsp. multocida str. P52VAC (1)
Pleurocybella porrigens (1)
Henipavirus nipahense (1)
Cryptococcus neoformans H99 (1)
Sus scrofa scrofa (1)
Rattus (1)
Cryptococcus neoformans (1)
Neisseria meningitidis (1)
Mesocricetus auratus (1)
Citrobacter koseri (1)
Caenorhabditis elegans (1)
Macaca mulatta (1)
mouse gut metagenome (1)
Plasmodium berghei (1)
Toxoplasma gondii (1)
unidentified (1)
Sus scrofa domesticus (1)

Repository

ENA (702)
geo (545)
biostudies-arrayexpress (169)
pride (122)
iProX (25)
MetaboLights (18)
jPOST (13)
MassIVE (10)
BioModels (8)
dbGaP (3)
ExpressionAtlas (2)
EGA (1)
GNPS (1)
PanoramaPublic (1)

Tissue

Brain (40)
Cell culture (27)
Blood plasma (10)
Brain microvascular endothelial cell (9)
Cerebrospinal fluid (9)
Blood (7)
Endothelial cell (7)
Epithelial cell (7)
Astrocyte (6)
Fibroblast (5)
Pluripotent stem cell (4)
Blood cell (3)
Macrophage (3)
Microvascular endothelial cell (3)
Blood-brain barrier (2)
Cerebral cortex endothelial cell (2)
Endothelial blood brain barrier (2)
Lung (2)
Pericyte cell (2)
Permanent cell line cell (2)
Placenta (2)
Smooth muscle cell (2)
Blood platelet (1)
Blood serum (1)
Blood vessel endothelial cell (1)
Brain cell line (1)
Brain microvessel endothelial cell (1)
Brain vascular cell (1)
Capillary endothelial cell (1)
Cell suspension culture (1)

Disease

Alzheimer's disease (8)
Breast cancer (6)
Brain glioblastoma multiforme (5)
Disease free (4)
Glioblastoma (4)
Multiple sclerosis (4)
Brain cancer (3)
Brain small vessel disease (3)
Bacterial meningitis (2)
Brain ischemia (2)
Human immunodeficiency virus infectious disease (2)
Parkinson's disease (2)
Type 2 diabetes mellitus (2)
Squamous cell carcinoma has accession C0007137 in DiseaseStateDatabase NCI_Thesaurus (1)
Chronic granulomatous disease (1)
IRAK-4 Q293X mutation (1)
Lung Neoplasms (1)
Alzheimer's disease 1 (1)
Amyotrophic lateral sclerosis type 1 (1)
Autism spectrum disorder (1)
Autistic disorder (1)
COVID-19 (1)
Cardiovascular system disease (1)
Chikungunya (1)
Diffuse midline glioma (1)
Down syndrome (1)
Epilepsy with generalized tonic-clonic seizures (1)
Huntington Disease (1)
Hydrocephalus (1)
Inflammation (1)

Technology Type

Mass Spectrometry (122)
Shotgun proteomics (60)
Bottom-up proteomics (32)
Data-independent acquisition (16)
Mass spectrometry (12)
Data-dependent acquisition (12)
SWATH MS (8)
Mass spectrometry assay (6)
Gel-based experiment (6)
Affinity purification coupled with mass spectrometry proteomics (4)
Top-down proteomics (3)
HDMSE (2)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
DiaPASEF (1)

Instrument Platform

Illumina NovaSeq 6000 (11)
NextSeq 500 (7)
Liquid Chromatography MS - positive - reverse phase (7)
Liquid Chromatography MS - negative - reverse phase (7)
Illumina HiSeq 4000 (5)
Orbitrap Fusion Lumos (3)
Liquid Chromatography MS - positive - reverse-phase (3)
Scanning hardware (2)
Q Exactive Plus (2)
Bruker Ultraflex (2)
Qubit 4 Fluorometer (1)
Agilent High resolution C scanner (1)
NextSeq 2000 (1)
Orbitrap Exploris 240 (1)
LTQ Orbitrap Pro (1)
LTQ Orbitrap Velos (1)
Orbitrap Eclipse (1)
Orbitrap Exploris 480 (1)
TimsTOF Pro (1)
TimsTOF fleX (1)
LCMS-IT-TOF (Shimadzu) (1)
QExactive (Thermo Scientific) (1)
Gas Chromatography MS - positive (1)
Liquid Chromatography MS - - reverse phase (1)
LTQ Orbitrap Discovery (Thermo Scientific) (1)
Liquid Chromatography MS - (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - negative - HILIC (1)
Liquid Chromatography MS - positive - HILIC (1)
Liquid Chromatography MS - negative - reverse-phase (1)

Publication Date

2025 (157)
2026 (117)
2024 (117)
2023 (90)
2022 (72)
2021 (53)
2015 (38)
2020 (32)
2016 (29)
2019 (29)
2013 (27)
2010 (25)
2014 (23)
2017 (19)
2012 (17)
2018 (16)
2009 (15)
2011 (14)
2008 (10)
2005 (7)
2007 (4)
2006 (1)
2004 (1)

UNIPROT ID/AC

P50148 (2)
P05067 (2)
P78352 (1)
Q13554 (1)
P50391 (1)
Q03169 (1)
P17861 (1)
Q13018 (1)
P04628 (1)
Q06787 (1)
P41221 (1)
Q14318 (1)
Q9Y618 (1)
O00755 (1)
O14936 (1)
O95388 (1)
P49768 (1)
P08069 (1)
P05019 (1)
P03372 (1)
P17655 (1)
Q9Y5W5 (1)
Q8TCB0 (1)
P04156 (1)
O75460 (1)
P98155 (1)
Q13492 (1)
Q8N8S7 (1)
Q13976 (1)
Q13541 (1)

CHEBI ID

CHEBI:29101 (3)
CHEBI:15361 (3)
CHEBI:15422 (3)
CHEBI:16761 (3)
CHEBI:16908 (3)
CHEBI:15846 (3)
CHEBI:18021 (3)
CHEBI:5656 (2)
CHEBI:26689 (2)
CHEBI:17287 (2)
CHEBI:422 (2)
CHEBI:4167 (2)
CHEBI:16004 (2)
CHEBI:15379 (2)
CHEBI:29052 (2)
CHEBI:29108 (2)
CHEBI:16027 (2)
CHEBI:17138 (2)
CHEBI:17234 (2)
CHEBI:24933 (1)
CHEBI:14484 (1)
CHEBI:6074 (1)
CHEBI:24932 (1)
CHEBI:1687 (1)
CHEBI:42317 (1)
CHEBI:1567 (1)
CHEBI:23616 (1)
CHEBI:20097 (1)
CHEBI:13960 (1)
CHEBI:23093 (1)

Metabolite Name

L-Histidine (5)
Creatine (5)
Kynurenic acid (4)
L-Glutamic acid (4)
Methionine (4)
L-Glutamine (4)
Hypoxanthine (4)
N-Acetyl-L-leucine (3)
2-Deoxyuridine (3)
LysoPC(15:0/0:0) (3)
Histidine (3)
Taurodeoxycholic acid (3)
L-Alanine (3)
Corticosterone (3)
Propionylcarnitine (3)
Thymine (3)
Allantoin (3)
N-lactoyl-phenylalanine (3)
Biliverdin (3)
Palmitoylcarnitine (3)
Cortisol (3)
Taurine (3)
Tauroursodeoxycholic acid (3)
4-Hydroxybenzaldehyde (3)
N-Decanoylglycine (3)
N-Undecanoylglycine (3)
Sebacic acid (3)
Malic acid (3)
Tyrosine (3)
Spermidine (3)

First Public Date

2025 (136)
2026 (125)
2024 (120)
2023 (67)
2022 (51)
2021 (46)
2020 (35)
2014 (34)
2019 (27)
2017 (18)
2018 (13)
2015 (13)
2016 (12)
2013 (5)

Modelling Approach

Ordinary differential equation model (5)
Machine learning (1)
Constraint-based model (1)

Study status

Terminated (1)

Lab affiliation

DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (4)
Physiopathology laboratory of the Blood Brain Barrier (2)
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China (2)
Translational Biomarker Group, University of Geneva, Geneva, Switzerland (2)
1) Vascular Biology Program, Boston Children's Hospital, Boston, MA, United States 2) Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States (1)
1Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA. Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA (1)
1Korea Brain Research Institute (1)
2Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125 (1)
Aalborg University Fredrik Bajersvej 3B 9220 Aalborg (1)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Assistant Professor, Neurology University of California, San Francisco (1)
Associate Professor (1)
Biomedical Sciences , Iowa State University (1)
Biomolecular characterization unit, Center for Sustainable Resource Science, RIKEN (1)
Brainstorm Brain Cancer Research, Brain and Mind Centre, University of Sydney, NSW, Australia School of Life and Environmental Science, University of Sydney, New South Wales, Australia (1)
CECAD Research Center, Institute for Genetics, University of Cologne, Cologne, Germany (1)
CIC bioGUNE Proteomics Platform Bizkaia Tech. Park Build 800 Derio 48160 Spain (1)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Chair of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Germany (1)
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden (1)
College of Veterinary Medicine, Southwest University, Chongqing 400715, China (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (1)
Dana Farber Cancer Institute, Boston, MA Harvard Medical School, Boston, MA (1)
Denali Therapeutics (1)
Departamento de Neuropatología Molecular. Instituto de Fisiología Celular. Universidad Nacional Autónoma de México (UNAM) (1)
Department for Biochemistry and Molecular Biology University of Southern Denmark Odense, Denmark (1)
Department for Drug Design and Pharmacology, University of Copenhagen (1)
Department of Anatomy & Neurobiology University of Tennessee Health Science Center (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Department of Biological Engineering, MIT (1)

Keyword

Durvalumab (1)

IsPrivate

False (8)

Model Flag

Non Kinetic (1)

Submitter Keywords

Ersilia (1)
FAIR-AIML (1)
Machine Learning Model (1)
Not Peer Reviewed (1)
Immuno-oncology (1)

Classification

bacteria (6)
fungi (2)
protozoa (2)
viruses (1)

Modification

15.994915 (2)
4x(15)N labeled L-arginine (1)
Not available (1)

Study type

Transcription profiling by array (123)
RNA-seq of coding RNA (20)
RNA-seq of coding RNA from single cells (5)
Cell line - High-throughput sequencing (3)
Comparative genomic hybridization by array (3)
RNA-seq of non coding RNA (3)
Unknown experiment type (2)
Animal - One-color microarray (2)
ChIP-chip by array (2)
Transcription profiling by SAGE (1)
Animal - Single-cell sequencing (1)
Cell line - One-color microarray (1)
Animal - High-throughput sequencing (1)
ChIP-seq (1)
RNA-seq of total RNA (1)
Interventional (1)

Release Date

2022 (1219)
2025 (1157)
2023 (1118)
2021 (1076)
2024 (929)
2020 (831)
2019 (617)
2018 (498)
2017 (428)
2016 (367)
2015 (276)
2014 (223)
2013 (181)
2026 (163)
2012 (132)
2010 (104)
2011 (100)
2009 (67)
2008 (45)
2007 (20)
2005 (15)
2006 (12)
2004 (6)
1999 (5)
2003 (4)
2000 (4)
2002 (2)
2001 (1)
1998 (1)

Location

United States (1)

Previous page
1 / 1106
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 1106
Next page

Sort by:

Relevance

Page size

A microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights

Culture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo

Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1...

ORGANISM(S): Mus musculus

2010-05-18 | E-GEOD-14375 | biostudies-arrayexpress

Fasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation

Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...

ORGANISM(S): Cellular Organisms

2024-08-15 | PXD044587 | JPOST Repository

Brain microvascular endothelial cells: INSR KD

The insulin receptor (INSR) mediates insulin signaling to modulate cellular functions. Although INSR is expressed at the blood-brain barrier (BBB), its role in the modulation of BBB function is poorly understood. Therefore, in this study, we aimed to analyze the effect of INSR knockdown on the expre...

ORGANISM(S): Homo Sapiens (human)

2021-12-25 | PXD027326 | JPOST Repository

Transcriptome analysis of 3D model of blood-brain barrier exposed to Borrelia garini

Using RNA sequencing to map differentially expressed genes in the 3D model of the blood-brain barrier ( composed of human brain endothelial cells, human astrocytes, and human pericytes) challenged with Borrelia garini .

ORGANISM(S): Homo sapiens

2021-01-01 | E-MTAB-9753 | biostudies-arrayexpress

Transcriptome analysis of 3D model of blood-brain barrier exposed to West Nile virus (WNV)

ORGANISM(S): Homo sapiens

2021-01-01 | E-MTAB-9754 | biostudies-arrayexpress

Transcriptome analysis of 3D model of blood-brain barrier exposed to tick-borne encephalitis virus (TBEV)

ORGANISM(S): Homo sapiens

2021-01-01 | E-MTAB-9755 | biostudies-arrayexpress

Interferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier

Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...

ORGANISM(S): Mus musculus

2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress

Microarray data from control and pericyte-deficient mouse brain microvascular transcriptomes

The blood-brain barrier (BBB) consists of specific physical barriers, enzymes and transporters, which together maintain the necessary extracellular environment of the central nervous system (CNS). The main physical barrier is found in the CNS endothelial cell, and depends on continuous complexes of ...

ORGANISM(S): Mus musculus

2010-10-21 | E-GEOD-15892 | biostudies-arrayexpress

BBBomics - Human Blood Brain Barrier Transcriptomics Hub [RNA-seq]

Functional and structural dysfunction of the blood brain barrier (BBB) leads to severe alterations in brain physiology and is believed to trigger neurodegeneration. To investigate the molecular mechanisms driving the BBB dysfunction, very few human BBB cell culture models are available; of which, th...

ORGANISM(S): Homo sapiens

2016-03-17 | E-GEOD-76528 | biostudies-arrayexpress

Previous page
1 / 1106
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 1106
Next page

Sort by:

Relevance

Page size

11055 Results

Show results for

Organisms

Organisms

Repository

Tissue

Disease

Technology Type

Instrument Platform

Publication Date

UNIPROT ID/AC

CHEBI ID

Metabolite Name

First Public Date

Modelling Approach

Study status

Lab affiliation

Tags

Keyword

IsPrivate

Model Flag

Submitter Keywords

Classification

Modification

Study type

Release Date

Location

OmicsDI is part of the ELIXIR infrastructure

Tweets